ANTIMICROBIAL ACTIVITY SCREENING OF BENZOTHIAZOLYL-PHENOTHIAZINE DERIVATIVES

Adriana GROZAV; Valentin ZAHARIA; Castelia CRISTEA; Nicodim Iosif FIT

Authors

Adriana GROZAV Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. *Corresponding author: adriana.ignat@umfcluj.ro https://orcid.org/0000-0001-5800-0896 (unauthenticated)
Valentin ZAHARIA Faculty of Pharmacy, “Iuliu Haţieganu” University of Medicine and Pharmacy, RO-400012, Victor Babes 41, Cluj-Napoca, Romania. https://orcid.org/0000-0001-7083-7680 (unauthenticated)
Castelia CRISTEA Faculty of Chemistry and Chemical Engineering, “Babeș-Bolyai” University, Cluj-Napoca, Romania. https://orcid.org/0000-0003-1138-2596 (unauthenticated)
Nicodim Iosif FIT Microbiology Department, Agricultural Sciences and Veterinary Medicine University, Cluj-Napoca, Romania. https://orcid.org/0000-0003-1062-1890 (unauthenticated)

Keywords:

phenothiazine, benzothiazole, antibacterial, diffusion, broth dilution, minimal inhibitory concentration

Abstract

The antimicrobial activity of a series of benzothiazolyl-10H-phenothiazine derivatives against Gram positive Bacteria (Staphylococcus aureus and Bacillus cereus), Gram negative Bacteria (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa) and fungus Candida albicans respectively, was screened using diffusion method and minimal inhibitory concentrations (MIC) were assessed by broth serial dilution procedure. Candida albicans, Bacillus cereus and Pseudomonas aeruginosa were proved to be susceptible to the benzothiazolyl-10H-phenothiazine derivatives (MIC 0.02-1.3 μg/mL).

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