ANTIOXIDANT ACTIVITY AND DFT STUDIES OF ETHYL 2-(2-((6-METHYL-4-OXO-4H-CHROMEN-3-YL) METHYLENE)HYDRAZINYL)THIAZOLE-4-CARBOXYLATE

Adriana GROZAV; Gabriel MARC; Cristina AZAROV; Violeta NECULA; Smaranda ONIGA; Tamas LOVASZ; Ovidiu CRIȘAN

doi:10.24193/subbchem.2026.1.15

ANTIOXIDANT ACTIVITY AND DFT STUDIES OF ETHYL 2-(2-((6-METHYL-4-OXO-4H-CHROMEN-3-YL) METHYLENE)HYDRAZINYL)THIAZOLE-4-CARBOXYLATE

Authors

Adriana GROZAV “Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 8 Victor Babes, Cluj-Napoca, RO-400012, Romania.
Gabriel MARC “Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 8 Victor Babes, Cluj-Napoca, RO-400012, Romania. *Corresponding author: marc.gabriel@umfcluj.ro https://orcid.org/0000-0001-9397-0388
Cristina AZAROV “Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 8 Victor Babes, Cluj-Napoca, RO-400012, Romania.
Violeta NECULA “Iuliu Hațieganu” University of Medicine and Pharmacy, ENT Department Cluj-Napoca, Romania. https://orcid.org/0000-0001-8415-555X
Smaranda ONIGA “Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Therapeutical Chemistry, 12 Ion Creangă, Cluj-Napoca, RO-400010, Romania. https://orcid.org/0000-0002-0297-7697
Tamas LOVASZ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0003-2923-7442
Ovidiu CRIȘAN “Iuliu Hațieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Organic Chemistry, 8 Victor Babes, Cluj-Napoca, RO-400012, Romania. https://orcid.org/0009-0009-7545-0800

DOI:

https://doi.org/10.24193/subbchem.2026.1.15

Keywords:

microwave-assisted synthesis, antioxidant activity, DFT calculation, chromene, thiazole

Abstract

ABSTRACT. The microwave-assisted improved synthesis of ethyl 2-(2-((6-methyl-4-oxo-4H-chromen-3-yl)methylene)hydrazinyl)thiazole-4-carboxylate is described. The antioxidant potential of the target compound was evaluated using spectrophotometric methods, including the DPPH• and ABTS•⁺ radical scavenging assays, as well as three additional electron-transfer assays employing metal-based oxidizing agents. The title compound exhibited good antioxidant activity compared to reference antioxidants. For the title compound theoretical quantum chemical (DFT) calculations were performed.

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STUDIA UBB CHEMIA, Volume 71 (LXXI), No. 1, March 2026

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Published

2026-03-25

How to Cite

GROZAV, A., MARC, G., AZAROV, C., NECULA, V., ONIGA, S., LOVASZ, T., & CRIȘAN, O. (2026). ANTIOXIDANT ACTIVITY AND DFT STUDIES OF ETHYL 2-(2-((6-METHYL-4-OXO-4H-CHROMEN-3-YL) METHYLENE)HYDRAZINYL)THIAZOLE-4-CARBOXYLATE. Studia Universitatis Babeș-Bolyai Chemia, 71(1), 245–256. https://doi.org/10.24193/subbchem.2026.1.15