ANTIMICROBIAL ACTIVITY SCREENING OF BENZOTHIAZOLYL-PHENOTHIAZINE DERIVATIVES

Adriana  GROZAV; Valentin  ZAHARIA; Castelia  CRISTEA; Nicodim Iosif  FIȚ

Authors

Adriana GROZAV Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: adriana.ignat@umfcluj.ro. https://orcid.org/0000-0001-5800-0896
Valentin ZAHARIA Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: vzaharia@umfcluj.ro. https://orcid.org/0000-0001-7083-7680
Castelia CRISTEA Faculty of Chemistry and Chemical Engineering, “Babeș-Bolyai” University, Cluj-Napoca, Romania. Email: castelia.cristea@ubbcluj.ro. https://orcid.org/0000-0003-1138-2596
Nicodim Iosif FIȚ Department of Microbiology, Immunology and Epidemiology, Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania. Email: nfit@usamvcluj.ro. https://orcid.org/0000-0003-1062-1890

Keywords:

phenothiazine, benzothiazole, antibacterial, diffusion, broth dilution, minimal inhibitory concentration

Abstract

The antimicrobial activity of a series of benzothiazolyl-10H-phenothiazine derivatives against Gram positive Bacteria (Staphylococcus aureus and Bacillus cereus), Gram negative Bacteria (Escherichia coli, Salmonella enteritidis, Pseudomonas aeruginosa) and fungus Candida albicans respectively, was screened using diffusion method and minimal inhibitory concentrations (MIC) were assessed by broth serial dilution procedure. Candida albicans, Bacillus cereus and Pseudomonas aeruginosa were proved to be susceptible to the benzothiazolyl-10H-phenothiazine derivatives (MIC 0.02-1.3 μg/mL).

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