N'-BENZYLIDENE-N-(THIAZOLYL)ACETOHYDRAZIDE DERIVATIVES: SYNTHESIS AND ANTIMICROBIAL ACTIVITY EVALUATION
DOI:
https://doi.org/10.24193/subbchem.2017.2.29Keywords:
acetohydrazide, thiazole, antimicrobialAbstract
A series of new N'-benzylidene-N-(thiazolyl)acetohydrazide derivatives was obtained by the acetylation of 2-(2-benzylidenehydrazinyl)thiazole derivatives using acetic anhydride. The antimicrobial activity of the new and parent compounds was screened against Gram-positive and Gram-negative bacteria using agar well diffusion method. 4-Methyl-2-[2-(4-hidroxibenzylidene)-hydrazinyl)-thiazole was identified as the most efficient, with a broad activity spectrum against both Gram positive and Gram negative bacteria.
References
M. C. Zanella, B. Kressmann, L. Wuarin, B. Coulin, S. Maître, D. Suva, B. A. Lipsky, I. Uçkay, Revue Mededicale Suisse, 2016,12, 514.
R. D. Kamble, R. J. Meshram, S. V. Hese, R. A. More, S. S. Kamble, R. N. Gacche, B. S. Dawane, Computational Biology and Chemistry, 2016, 61, 86.
N. Seelam, S. P. Shrivastava, Journal of Saudi Chemical Society, 2016, 20, 33.
S. Bondock, T. Naser, Y. A. Ammar, European Journal of Medicinal Chemistry, 2013, 62, 270.
E. B. Silva, D. A. O. Silva, A. R. Oliveira, C. H. S. Mendesa, T. A. R. Santosc, A. C. Silva, M. C. A. Castro, R. S. Ferreira, D. R. M. Moreira, M. V. O. Cardoso, C. A. Simone, V. R. A. Pereirac, A. C. L. Leitea, European Journal of Medicinal Chemistry, 2017, 130, 39.
T. A. R. Santos, A. C. Silva, E. B. Silva, P. A.T. Moraes Gomes, J. W. P. Espíndola, M. V. O. Cardoso, D. R. M. Moreira, A. C. L. Leite, V. R. A. Pereira, Biomedicine & Pharmacotherapy, 2016, 82, 555.
G. M. Reddy, J. R. Garcia, V. H. Reddy, A. M. Andrade, A. Camilo, R. A. P. Ribeiro, S. R. de Lazaro, European Journal of Medicinal Chemistry, 2016, 123, 508.
N. Siddiqui, W. Ahsan, European Journal of Medicinal Chemistry, 2010, 45, 1536.
A. Andreani, M. Rambaldi, F. Andreani, R. Bossa, I. Galatulas, European Journal of Medicinal Chemistry, 1988, 23, 385.
Z. Gao-Feng, J. Leng, N. Darshini, T. Shubhavathi, H. K. Vivek, A. M. Asiri, H. M. Marwani, K. P. Rakesh, N. Mallesha, N. Bionda, R. Fleeman, H. Wang, A. Ozawa, R. A. Houghten, L. Shaw, Bioorganic & Medicinal Chemistry Letters, 2017, 27(14), 3148.
Y. Li, N. Bionda, R. Fleeman, H. Wang, A. Ozawa, R. A. Houghten, L. Shaw, Bioorganic & Medicinal Chemistry, 2016, 24, 5633.
A. Andreani, A. Leoni, A. Locatelli, R. Morigi, M. Rambaldi, R. Cervellati, E. Greco, T. P. Kondratyuk, E. J. Park, K. Huang, R. B. Breemen, J. M. Pezzuto, European Journal of Medicinal Chemistry, 2013, 68, 412.
A. Grozav, I. D. Porumb, L. I. Găină, L. Filip, D. Hanganu, Molecules, 2017, 22, 260.
A. Grozav, L. I. Găină, V. Pileczki, O. Crisan, L.Silaghi-Dumitrescu, B. Therrien, V. Zaharia, I. Berindan-Neagoe, International Journal of Molecular Science, 2014, 15, 22059.
M. Sabou, A. Grozav, L. M. Junie, M. Flota, V. Zaharia, C. Cristea, Studia UBB Chemia, 2016, 61, 117.
A. Ignat, T. Lovasz, M. Vasilescu, E. Fischer-Fodor, C. B. Tatomir, C. Cristea, L. Silaghi-Dumitrescu, V. Zaharia, Archiv der Pharmacie Chemistry in Life Sciences 2012, 345, 574.
V. Zaharia, A. Ignat, N. Palibroda, B. Ngameni, V. Kuete, C. N. Fokunang, M. L. Moungang, B. T. Ngadjui, European Journal of Medicinal Chemistry, 2010, 45, 5080.
A. Ignat, V. Zaharia, C. Mogosan, N. Palibroda, C. Cristea, L. Silaghi-Dumitrescu, Farmacia, 2010, 58, 290.
B. Brem, E. Gal, C. Cristea, L. Găină, A. Grozav, V. Zaharia, L. Silaghi-Dumitrescu, Studia UBB Chemia, 2015, 60 (2), 320.
B. Markey, F. Leonard, M. Archambault, A. Cullinane, D. Maguire, Clinical Veterinary Microbiology, Second edition, Elsevier, 2013.
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