SYNTHESIS AND CHARACTERIZATION OF MUC-1 FUNCTIONALIZED GOLD NANOPARTICLES

Cristian Tudor MATEA; Teodora MOCAN; Flaviu TABARAN; Teodora POP; Ofelia MOSTEANU; Lucian Constantin  MOCAN; Claudiu-Dragoș  ZDREHUȘ

doi:10.24193/subbchem.2018.3.10

Authors

Cristian Tudor MATEA Department of Nanomedicine, “Octavian Fodor” Gastroenterology Institute, Cluj-Napoca, Romania. https://orcid.org/0000-0002-5036-3454 (unauthenticated)
Teodora MOCAN Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Nanomedicine, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania. *Corresponding author: teodora.mocan@umfcluj.ro. https://orcid.org/0000-0001-9925-0998 (unauthenticated)
Flaviu TABARAN Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Nanomedicine, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania. https://orcid.org/0000-0001-5744-0451 (unauthenticated)
Teodora POP 3rd Gastroenterology Department “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Ofelia MOSTEANU 3rd Gastroenterology Department “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ofeliamosteanu@gmail.com. https://orcid.org/0000-0002-7469-4493 (unauthenticated)
Lucian Constantin MOCAN 3rd Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy; Department of Nanomedicine, “Octavian Fodor” Gastroenterology Institute, Cluj-Napoca, Romania. Email: mocanlucian@yahoo.com. https://orcid.org/0000-0002-7444-7978 (unauthenticated)
Claudiu-Dragoș ZDREHUȘ 3rd Surgery Clinic “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: czdrehus@yahoo.com. https://orcid.org/0000-0002-7333-5405 (unauthenticated)

DOI:

https://doi.org/10.24193/subbchem.2018.3.10

Keywords:

gold nanoparticles, functionalization, MUC-1 peptide

Abstract

Gold nanoparticles have been functionalized with the biologically active MUC-1 peptide conjugated to KLH and the obtained bio-nanostructure was characterized using an array of techniques such as: UV-Vis and ATR-FT-IR spectroscopy, dynamic light scattering (DLS) and atomic force microscopy (AFM). A 54 nm monodisperse bio-nanostructure with high aqueous stability was obtained.

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SYNTHESIS AND CHARACTERIZATION OF MUC-1 FUNCTIONALIZED GOLD NANOPARTICLES

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