SYNTHESIS AND CHARACTERIZATION OF MUC-1 FUNCTIONALIZED GOLD NANOPARTICLES

Authors

  • Cristian Tudor MATEA Department of Nanomedicine, “Octavian Fodor” Gastroenterology Institute, Cluj-Napoca, Romania. Corresponding author: teodora.mocan@umfcluj.ro. https://orcid.org/0000-0002-5036-3454
  • Teodora MOCAN Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Nanomedicine, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania. Email: teodora.mocan@umfcluj.ro. https://orcid.org/0000-0001-9925-0998
  • Flaviu TABARAN Department of Physiology, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Nanomedicine, Regional Institute of Gastroenterology and Hepatology, Cluj-Napoca, Romania. Corresponding author: teodora.mocan@umfcluj.ro. https://orcid.org/0000-0001-5744-0451
  • Teodora POP 3rd Gastroenterology Department “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: teodora.mocan@umfcluj.ro.
  • Ofelia MOSTEANU 3rd Gastroenterology Department “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ofeliamosteanu@gmail.com. https://orcid.org/0000-0002-7469-4493
  • Lucian Constantin MOCAN 3rd Surgery Clinic, “Iuliu Hatieganu” University of Medicine and Pharmacy; Department of Nanomedicine, “Octavian Fodor” Gastroenterology Institute, Cluj-Napoca, Romania. Email: mocanlucian@yahoo.com. https://orcid.org/0000-0002-7444-7978
  • Claudiu-Dragoș ZDREHUȘ 3rd Surgery Clinic “Iuliu Hatieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: czdrehus@yahoo.com. https://orcid.org/0000-0002-7333-5405

DOI:

https://doi.org/10.24193/subbchem.2018.3.10

Keywords:

gold nanoparticles, functionalization, MUC-1 peptide

Abstract

Gold nanoparticles have been functionalized with the biologically active MUC-1 peptide conjugated to KLH and the obtained bio-nanostructure was characterized using an array of techniques such as: UV-Vis and ATR-FT-IR spectroscopy, dynamic light scattering (DLS) and atomic force microscopy (AFM). A 54 nm monodisperse bio-nanostructure with high aqueous stability was obtained.

References

N. Elahi; M. Kamali; M.H. Bachersad, Talanta 2018, 184, 537.

A. Gharatape; R. Salehi, European Journal of Medicinal Chemistry 2017, 138, 221.

L. Mocan; F.A. Tabaran; T. Mocan; T. Pop; O. Mosteanu; L. Agoston-Coldea; C. T. Matea; D. Gonciar; C. Zdrehus; C. Iancu, International Journal of Nanomedicine 2017, 12, 2255.

T. Mocan; C.T. Matea; T. Pop; O. Mosteanu; A.D. Buzoianu; S. Suciu; C. Puia; C. Zdrehus; C. Iancu; L. Mocan, Cellular and Molecular Life Sciences 2017, 74 (19), 3467.

S. Bathia, Nanoparticles Types, Classification, Characterization, Fabrication Methods and Drug Delivery Applications. In Natural Polymer Drug Delivery Systems, Springer, Cham: 2016.

B. Duncan; C. Kim; V.M. Rotello, Journal of Controlled Release 2010, 148 (1), 122.

C.T. Matea; T. Mocan; F. Tabaran; C. Iancu; L. Mocan, Journal of Nanobiotechnology 2015, 13 (41).

Z.P. Xu; Q.H. Zeng; G.Q. Lu; A.B. Yu, Chemical Engineering Science 2006, 61 (3), 1027.

D.W. McFadden; D.R. Riggs; B.J. Jackson; A. Ng; C. Cunningham, The American Journal of Surgery 2007, 193 (2), 284.

S.K. Kim; G. Ragupathi; C. Musselli; S.-J. Choi; Y.S. Park; P.O. Livingston, Vaccine 2000, 18, 597.

T. Mocan; C. Matea; F. Tabaran; C. Iancu; R. Orasan; L. Mocan, Journal of Cancer 2015, 6 (6), 583.

D.R. Baer; M.H. Engellhard; G E. johnson; J. Laskin; J. Lai; K. Mueller; P. Munusamy; S. Thevuthasan; H. Wang; N. Washton, Jornal of Vacuum Science and Technology A 2013, 31 (5).

L. Shang; Y. Wang; J. Jiang; S. Dong, Langmuir 2007, 23, 2714-2721.

Y. Wang; Y. Ni, Talanta 2014, 119, 320.

G. Mandal; M. Bardhan; T. Ganguly, Colloids and Surfaces B: Biointerfaces 2010, 81 (178-184).

J. Park; J. Shumaker-Parry, Journal of the American Chemical Society 2014, 136, 1907-1921.

X. Zou; E. Ying; S. Dong, Nanotechnology 2006, 17 (4758-4764).

STUDIA UBB CHEMIA, Volume 63 (LXIII), No. 3, September 2018

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Published

2018-09-28

How to Cite

MATEA, C. T. ., MOCAN, T. ., TABARAN, F. ., POP, T. ., MOSTEANU, O., MOCAN, L. C. ., & ZDREHUȘ, C.-D. . (2018). SYNTHESIS AND CHARACTERIZATION OF MUC-1 FUNCTIONALIZED GOLD NANOPARTICLES. Studia Universitatis Babeș-Bolyai Chemia, 63(3), 129–135. https://doi.org/10.24193/subbchem.2018.3.10

Issue

Volume 63, No. 3, 2018

Section

Articles

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