INFLUENCE OF TABLET FORMULATION ON IN VITRO  RELEASE OF MAGNESIUM

Corina Florentina  MOISA; Maria-Alexandra  RESZ (HOAGHIA); Dorina  SIMEDRU; Oana  CADAR

INFLUENCE OF TABLET FORMULATION ON IN VITRO RELEASE OF MAGNESIUM

Authors

Corina Florentina MOISA Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Romania. Corresponding author: oana.cadar@icia.ro. https://orcid.org/0000-0001-9918-250X
Maria-Alexandra RESZ (HOAGHIA) Research Institute for Analytical Instrumentation (INCDO-INOE 2000), Cluj-Napoca, Romania. Corresponding author: oana.cadar@icia.ro. https://orcid.org/0000-0001-5903-1491
Dorina SIMEDRU Research Institute for Analytical Instrumentation (INCDO-INOE 2000), Cluj-Napoca, Romania. Email: dorina.simedru@icia.ro. https://orcid.org/0000-0003-4914-6986
Oana CADAR Research Institute for Analytical Instrumentation (INCDO-INOE 2000), Cluj-Napoca, Romania. Email: oana.cadar@icia.ro. https://orcid.org/0000-0002-0879-9211

Keywords:

magnesium release, in vitro, pH, matrix tablet

Abstract

The transfer of active substances of pharmaceutical forms is influenced by several factors, among which the nature of the excipients used in compression. The objective of this study was to investigate the influence of cellulose and its derivatives (hydroxypropylcellulose, hydroxylpropylmethylcellulose, carboxymethylcellulose) on the release profile of magnesium from marketed tablets (T1-T4). In vitro release experiments were carried out using a dissolution apparatus, in ultrapure water and simulated intestinal fluid (pH=6.8). In selected formulations, the amount of magnesium released was determined using inductively coupled plasma optical emission spectrometry (ICP-OES). The magnesium dissolution profiles demonstrated complete dissolution for T1, even just after 5 min. Magnesium release rate decreased with the increase in cellulose and/or its derivatives proportion: T1<T3<T2<T4. An agitation speed of 50 rpm showed a more satisfactory magnesium release profile than 100 rpm.

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STUDIA UBB CHEMIA, Volume 61 (LXI), No. 3, September 2016

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Published

2016-09-30

How to Cite

MOISA, C. F. ., RESZ (HOAGHIA), M.-A. ., SIMEDRU, D. ., & CADAR, O. . (2016). INFLUENCE OF TABLET FORMULATION ON IN VITRO RELEASE OF MAGNESIUM. Studia Universitatis Babeș-Bolyai Chemia, 61(3), 441–449. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8367