ANTIMICROBIAL ACTIVITY OF EXPERIMENTAL ENDODONTIC SEALER BASED ON BIOCERAMIC NANOMATERIALS

Lucia Iacobina TIMIȘ; Maria GOREA; Carmen Anca COSTACHE; Ioana Alina COLOSI; Pavel ȘCHIOPU; Paul-Ștefan PANAITESCU; Ada DELEAN; Dinu Iuliu DUMITRASCU; Radu Septimiu CÂMPIAN

doi:10.24193/subbchem.2021.4.27

ANTIMICROBIAL ACTIVITY OF EXPERIMENTAL ENDODONTIC SEALER BASED ON BIOCERAMIC NANOMATERIALS

Authors

Lucia Iacobina TIMIȘ Department of Odontology, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: timis.lucia@umfcluj.ro.
Maria GOREA Department of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: maria.gorea@ubbcluj.ro.
Carmen Anca COSTACHE Department of Molecular Sciences, Division of Microbiology, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: anca.costache@umfcluj.ro. https://orcid.org/0000-0003-2640-0072
Ioana Alina COLOSI Department of Molecular Sciences, Division of Microbiology, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: icolosi@umfcluj.ro.
Pavel ȘCHIOPU Department of Molecular Sciences, Division of Microbiology, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: pschiopu@umfcluj.ro. https://orcid.org/0000-0002-0302-4505
Paul-Ștefan PANAITESCU Department of Molecular Sciences, Division of Microbiology, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ppanaitescu@umfcluj.ro. https://orcid.org/0000-0002-7743-0995
Ada DELEAN Department of Odontology, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ada.delean@umfcluj.ro. https://orcid.org/0000-0003-4284-2209
Dinu Iuliu DUMITRASCU Department of Anatomy and Embryology, Faculty of Medicine, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ddumitrascu@umfcluj.ro. https://orcid.org/0000-0001-8042-1582
Radu Septimiu CÂMPIAN Department of Oral Rehabilitation, Faculty of Dentistry, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: timis.lucia@umfcluj.ro. https://orcid.org/0000-0001-6233-8822

DOI:

https://doi.org/10.24193/subbchem.2021.4.27

Keywords:

antimicrobial activity, bioceramic, endodontic sealer, tricalcium silicate.

Abstract

ABSTRACT. The aim of this work was to evaluate the antimicrobial effectiveness of a bioceramic experimental endodontic sealer (EES), alongside with its components. As a novelty, magnesium silicate was incorporated into the experimental material, in order to improve the mechanical performance of the product. The main oxide components, tricalcium silicate (Ca₃SiO₅) and magnesium silicate (Mg₂SiO₄) were synthesized in nanoparticles from specific precursors by a sol-gel method. To compare the efficiency of the new developed product, commercially available materials, with similar chemical composition, used in everyday practice, were also tested: BC Sealer, MTA Bioceramic Root Canal Sealer, and MTA Fillapex. The method employed for the present study was the agar well diffusion test (ADT). The selected microbial strains were Enterococcus faecalis and Candida albicans, frequently associated with persistent infection and recurrent infections of the endodontic space, as well as periapical pathologies refractory to endodontic treatment. Measurements of the inhibition areas were performed at 24-hour intervals for 7 consecutive days. Tricalcium silicate and all tested endodontic sealers revealed antimicrobial effectiveness against Candida albicans at 24 hours after placement, with a prolonged activity, for up to 7 days. The study revealed no antibacterial effect against Enterococcus faecalis at 24 hours nor in the following 7 days, for any of the tested samples.

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STUDIA UBB CHEMIA, Volume 66 (LXVI), No. 4, December 2021

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Published

2021-12-30

How to Cite

TIMIȘ, L. I., GOREA, M., COSTACHE, C. A., COLOSI, I. A., ȘCHIOPU, P., PANAITESCU, P.- Ștefan, … CÂMPIAN, R. S. (2021). ANTIMICROBIAL ACTIVITY OF EXPERIMENTAL ENDODONTIC SEALER BASED ON BIOCERAMIC NANOMATERIALS. Studia Universitatis Babeș-Bolyai Chemia, 66(4), 369–382. https://doi.org/10.24193/subbchem.2021.4.27