THIAZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY AGAINST CANDIDA SPECIES

Mihaela  SABOU; Adriana  GROZAV; Lia Monica  JUNIE; Mirela  FLONTA; Valentin  ZAHARIA; Castelia  CRISTEA

THIAZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY AGAINST CANDIDA SPECIES

Authors

Mihaela SABOU Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: adriana.ignat@umfcluj.ro.
Adriana GROZAV Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: adriana.ignat@umfcluj.ro. https://orcid.org/0000-0001-5800-0896
Lia Monica JUNIE Faculty of Medicine, “Iuliu Haţieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: mjunie@umfcluj.ro. https://orcid.org/0000-0002-3550-7966
Mirela FLONTA Hospital of Infectious Diseases, Cluj-Napoca, Romania. Corresponding author: adriana.ignat@umfcluj.ro. https://orcid.org/0000-0001-5478-8815
Valentin ZAHARIA Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: vzaharia@umfcluj.ro. https://orcid.org/0000-0001-7083-7680
Castelia CRISTEA Faculty of Chemistry and Chemical Engineering, “Babeș-Bolyai” University, Cluj-Napoca, Romania. Email: castelia.cristea@ubbcluj.ro. https://orcid.org/0000-0003-1138-2596

Keywords:

Thiazole, Benzothiazole, Phenothiazine, Candida species

Abstract

The antifungal activity of a series of thiazole, benzothiazole and benzothiazolyl-phenothiazine derivatives against Candida albicans and non-Candida albicans species causing invasive candidiasis was investigated using the diffusion method and the broth dilution procedure. Minimal inhibitory concentrations revealed antifungal activity against C. albicans, C. guillermondii, C. krusei and C. parapsilosis strains isolated from clinical materials (blood, urine and peritoneal fluids cultures). The tested hydrazine-thiazole derivatives showed promising antifungal activity against both fluconazole susceptible and resistive Candida species, while the benzothiazolyl-phenothiazine derivatives were not effective.

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STUDIA UBB CHEMIA, Volume 61 (LXI), No. 3, September 2016

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Published

2016-09-30

How to Cite

SABOU, M. ., GROZAV, A. ., JUNIE, L. M. ., FLONTA, M. ., ZAHARIA, V. ., & CRISTEA, C. . (2016). THIAZOLE DERIVATIVES WITH ANTIFUNGAL ACTIVITY AGAINST CANDIDA SPECIES. Studia Universitatis Babeș-Bolyai Chemia, 61(3), 117–123. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8337