Formulation and Evaluation of Antifungal Miconazole Nitrate Medicated Soap

Authors

  • Emőke Margit RÉDAI Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: emoke.redai@umfst.ro https://orcid.org/0000-0002-1186-4125
  • Orsolya PÉTERFI Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: emoke.redai@umfst.ro https://orcid.org/0000-0002-1921-1452
  • Robert Alexandru VLAD Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: robert.vlad@umfst.ro
  • Paula ANTONOAEA Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: paula.antonoaea@umftgm.ro https://orcid.org/0000-0002-8380-966X
  • Nicoleta TODORAN Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: nicoleta.todoran@umfst.ro https://orcid.org/0000-0001-6474-6248
  • Adriana CIURBA Department of Pharmaceutical Technology and Cosmetology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: adriana.ciurba@umfst.ro https://orcid.org/0000-0002-3456-4109
  • Ibolya Zita FÜLÖP Department of Toxicology and Biopharmacy, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Corresponding author: ibolya.fulop@umfst.ro https://orcid.org/0000-0003-3973-3458
  • Enikő BARABÁS Department of Cellular Biology and Microbiology, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: eniko.barabas@umfst.ro https://orcid.org/0000-0002-1830-7356
  • Emese SIPOS Department of Drugs Industry and Pharmaceutical Management, Faculty of Pharmacy, “George Emil Paladeˮ University of Medicine, Pharmacy, Science and Technology, Targu Mures, Romania. Email: emese.sipos@umfst.ro https://orcid.org/0000-0002-1820-244X

DOI:

https://doi.org/10.24193/subbchem.2024.4.05

Keywords:

miconazole, medicated soap, Candida albicans, olive oil

Abstract

Miconazole nitrate containing soaps were formulated using one commercially available soap base and three cold process soap bases with various lipids. The aim of our work was to investigate the antimicrobial activity and physicochemical properties of the obtained formulations. The water loss and hardness of the soaps was determined 1, 2, 4 and 9 weeks after preparation. The pH and foamability were determined after 9 weeks of curing time. Two Gram-positive, four Gram-negative bacteria and two yeast (Candida spp.) strains were used in the microbial study. The miconazole content was determined with HPLC-UV analysis. Antimicrobial assay showed that all medicated soaps were effective against Candida albicans. The API had minimal influence on the physicochemical properties (water loss, pH, foamability and consistency) of the soaps. All soaps possessed good lathering properties and an alkaline pH (9.2-11.3). The miconazole content of the soaps varied from 2.72 % to 5.12 % as revealed by HPLC-UV analysis.

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STUDIA UBB CHEMIA, Volume 69 (LXIX), No. 4, December 2024

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Published

2024-12-18

How to Cite

RÉDAI, E. M., PÉTERFI, O., VLAD, R. A., ANTONOAEA, P., TODORAN, N., CIURBA, A., … SIPOS, E. (2024). Formulation and Evaluation of Antifungal Miconazole Nitrate Medicated Soap. Studia Universitatis Babeș-Bolyai Chemia, 69(4), 67–83. https://doi.org/10.24193/subbchem.2024.4.05

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Volume 69, No. 4, 2024

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