SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 5-AMINO-2-MERCAPTO-1,3,4-THIADIAZOLE DERIVATIVES THIOETERS AND SCHIFF BASES

Oana  RAD; Rózsa  TIBOR; Mihaela  DUMA; Laurian  VLASE; Adrian  PÎRNĂU; Brînduşa  TIPERCIUC; Ioana  IONUŢ; Ovidiu  ONIGA

SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 5-AMINO-2-MERCAPTO-1,3,4-THIADIAZOLE DERIVATIVES THIOETERS AND SCHIFF BASES

Authors

Oana RAD Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: ionut.ioana@umfcluj.ro.
Rózsa TIBOR Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: ionut.ioana@umfcluj.ro. https://orcid.org/0000-0003-4705-9977
Mihaela DUMA State Veterinary Laboratory for Animal Health and Food Safety, Cluj-Napoca, Romania. Corresponding author: ionut.ioana@umfcluj.ro. https://orcid.org/0000-0002-4438-7425
Laurian VLASE Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy; Department of Clinical Pharmacology and Pharmacokinetics. Email: laurian.vlase@umfcluj.ro. https://orcid.org/0000-0002-0664-3387
Adrian PÎRNĂU National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Corresponding author: ionut.ioana@umfcluj.ro. https://orcid.org/0000-0002-2313-9350
Brînduşa TIPERCIUC Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: btiperciuc@umfcluj.ro. https://orcid.org/0000-0002-6732-5147
Ioana IONUŢ Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ionut.ioana@umfcluj.ro. https://orcid.org/0000-0001-6073-6616
Ovidiu ONIGA Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ooniga@umfcluj.ro.

Keywords:

1,3,4-thiadiazole, antibacterial activity, antifungal activity

Abstract

Starting from 5-amino-2-mercapto-1,3,4-thiadiazole, 23 compounds, Schiff bases and S-mercapto-substituted derivatives were synthesized. Their structural elucidation was based on elemental analysis, mass spectrometry and proton nuclear magnetic resonance spectroscopy (^¹H NMR). The screening of the antimicrobial activity of the title compounds was realized using the diffusimetric method against several strains of Gram-positive and Gram-negative bacteria and one fungal strain (Candida albicans). Some of the molecules showed moderate to good antibacterial activity against Gram-negative (S. typhimurium, E. coli) and better activity against Gram-positive (B. cereus, L. monocytogenes, S. aureus) bacterial strains. All compounds exhibited moderate to very good activity against C. albicans. Qualitative relationships (SAR) were also established between the chemical structures and the antimicrobial activity of these compounds.

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STUDIA UBB CHEMIA, Volume 61 (LXI), No. 1, March 2016

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Published

2016-03-30

How to Cite

RAD, O. ., TIBOR, R. ., DUMA, M. ., VLASE, L. ., PÎRNĂU, A. ., TIPERCIUC, B. ., … ONIGA, O. . (2016). SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF SOME 5-AMINO-2-MERCAPTO-1,3,4-THIADIAZOLE DERIVATIVES THIOETERS AND SCHIFF BASES. Studia Universitatis Babeș-Bolyai Chemia, 61(1), 17–32. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8276