CYTOTOXIC ACTIVITY OF PALLADIUM (II) COMPLEXES OF (1E,6E)-1,7-BIS(4-(DIMETHYLAMINO)PHENYL)HEPTA-1,6-DIENE-3,5-DIONE AGAINST HUMAN COLON CARCINOMA

Natalia MIKLÁŠOVÁ; Roman MIKLÁŠ; Piroska VIRAG; Corina Bianca TATOMIR; Cristina SZALONTAI; Diana CENARIU; Ferdinand DEVÍNSKY; Eva FISCHER-FODOR

Authors

Natalia MIKLÁŠOVÁ Research Department, Comprehensive Cancer Center, "Prof. Dr. I. Chiricuta" Institute of Oncology, Cluj-Napoca, Romania. https://orcid.org/0000-0002-8682-1760
Roman MIKLÁŠ Research Department, Comprehensive Cancer Center, "Prof. Dr. I. Chiricuta" Institute of Oncology, Cluj-Napoca, Romania. https://orcid.org/0000-0002-7899-3474
Piroska VIRAG Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia. https://orcid.org/0000-0002-2545-6640
Corina Bianca TATOMIR Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia. https://orcid.org/0000-0002-2441-3737
Cristina SZALONTAI Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia.
Diana CENARIU Faculty of Medicine, Iuliu Hatieganu University of Medicine and Pharmacy Cluj-Napoca, Romania. https://orcid.org/0000-0002-1024-1479
Ferdinand DEVÍNSKY Research Department, Comprehensive Cancer Center, "Prof. Dr. I. Chiricuta" Institute of Oncology, Cluj-Napoca, Romania. https://orcid.org/0000-0002-8059-9994
Eva FISCHER-FODOR Department of Chemical Theory of Drugs, Faculty of Pharmacy, Comenius University, Bratislava, Slovakia. *Corresponding author: fischer.eva@iocn.ro. https://orcid.org/0000-0002-0898-0547

Keywords:

palladium complexes, curcumin derivative, cytotoxicity, colon cancer, cellular uptake

Abstract

Two palladium(II) complexes of (1E,6E)-1,7-bis(4-(dimethilamino) phenyl)hepta-1,6-diene-3,5-dione were synthesized and structurally characterized with the aim of testing their cytotoxicity towards human colon tumor cells in vitro. Complexes A and B have the capacity to inhibit the cell growth in HT-29 and DLD-1 cell lines, the activity of A being superior as a result of a better accumulation inside the tumor cells.

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