KINETICS OF ZOLPIDEM AND ITS METABOLITE  AFTER SINGLE DOSE ORAL ADMINISTRATION

Ana-Maria  GHELDIU; Alexandra  CSAVDÁRI; Marcela  ACHIM; Laurian  VLASE; Ioan  TOMUȚĂ; Dana Maria  MUNTEAN

doi:10.24193/subbchem.2017.2.13

KINETICS OF ZOLPIDEM AND ITS METABOLITE AFTER SINGLE DOSE ORAL ADMINISTRATION

Authors

Ana-Maria GHELDIU Department of Pharmaceutical Botany, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: anamaria.gheldiu@yahoo.com. https://orcid.org/0000-0003-4865-0777
Alexandra CSAVDÁRI Department of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University of Cluj-Napoca, Romania. Email: acsavdari@chem.ubbcluj.ro. https://orcid.org/0000-0003-4321-5610
Marcela ACHIM Department of Pharmaceutical Technology and Biopharmaceutics, ‟Iuliu Hatieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania. Email: machim@umfcluj.ro. https://orcid.org/0000-0002-0184-3144
Laurian VLASE Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy; Department of Clinical Pharmacology and Pharmacokinetics. Email: laurian.vlase@umfcluj.ro. https://orcid.org/0000-0002-0664-3387
Ioan TOMUȚĂ Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: tomutaioan@umfcluj.ro. https://orcid.org/0000-0002-5094-008X
Dana Maria MUNTEAN Department of Pharmaceutical Technology and Biopharmaceutics, ‟Iuliu Hatieganu” University of Medicine and Pharmacy, Faculty of Pharmacy, Cluj-Napoca, Romania. Email: dana.muntean@umfcluj.ro. https://orcid.org/0000-0002-0200-1280

DOI:

https://doi.org/10.24193/subbchem.2017.2.13

Keywords:

zolpidem, zolpidem phenyl-4-carboxylic acid, compartmental pharmacokinetic analysis

Abstract

The present study aimed to describe the basic pharmacokinetics of zolpidem and its metabolite zolpidem phenyl-4-carboxylic acid after a single oral dose of 5 mg zolpidem. Six competing kinetic models were created in order to analyze the experimental data obtained from the 20 healthy volunteers enrolled in a clinical study. Based on rational model discrimination criteria (Akaike index value), the best one was chosen and further used for a better understanding of the kinetics of zolpidem and its metabolite in the body after administration. The kinetic model considers that zolpidem absorption process follows a first-order kinetics and during this stage, it is partially metabolized (pre-systemic metabolism) to its main metabolite. The kinetics of both zolpidem and its metabolite is characterized by bicompartmental distribution and first order kinetics of both elimination and systemic metabolism.

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STUDIA UBB CHEMIA, Volume 62 (LXII), No. 2, Tome II, June 2017

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Published

2017-06-30

How to Cite

GHELDIU, A.-M. ., CSAVDÁRI, A. ., ACHIM, M. ., VLASE, L. ., TOMUȚĂ, I. ., & MUNTEAN, D. M. . (2017). KINETICS OF ZOLPIDEM AND ITS METABOLITE AFTER SINGLE DOSE ORAL ADMINISTRATION. Studia Universitatis Babeș-Bolyai Chemia, 62(2), 179–188. https://doi.org/10.24193/subbchem.2017.2.13