PREPARATION AND CHARACTERIZATION OF HYDROXYAPATITE BASED NANO-COMPOSITE BIOMORPHIC IMPLANTS

Réka  BARABÁS; Melinda  RIGÓ; Margit  ENISZNÉ-BÓDOGH; Corina Florentina  MOISA; Oana  CADAR

doi:10.24193/subbchem.2018.3.11

PREPARATION AND CHARACTERIZATION OF HYDROXYAPATITE BASED NANO-COMPOSITE BIOMORPHIC IMPLANTS

Authors

Réka BARABÁS Department of Chemistry and Chemical Engineering, Hungarian Line of Study, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: reka.barabas@ubbcluj.ro. https://orcid.org/0000-0001-6730-084X
Melinda RIGÓ Department of Chemistry and Chemical Engineering, Hungarian Line of Study, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Corresponding author: oana.cadar@icia.ro. https://orcid.org/0000-0003-0804-9629
Margit ENISZNÉ-BÓDOGH Institute of Materials Engineering, University of Pannonia, Veszprem, Hungary. Corresponding author: oana.cadar@icia.ro.
Corina Florentina MOISA Department of Pharmacy, Faculty of Medicine and Pharmacy, University of Oradea, Romania. Corresponding author: oana.cadar@icia.ro. https://orcid.org/0000-0001-9918-250X
Oana CADAR Research Institute for Analytical Instrumentation (INCDO-INOE 2000), Cluj-Napoca, Romania. Email: oana.cadar@icia.ro. https://orcid.org/0000-0002-0879-9211

DOI:

https://doi.org/10.24193/subbchem.2018.3.11

Keywords:

biomorphic implants, hydroxyapatite, gelatin, carbon nanotubes, ibuprofen

Abstract

The aim of this study was the preparation and characterization of different biomorphic implants based on calcined cattle bones coated with hydroxyapatite (Hap) based nanocomposites in different ratios. For comparison, molded nanocomposites were also produced as biomorphic implants. The obtained nanocomposite/implants were characterized using X-ray diffraction, light microscopy and scanning electron microscopy, Brunauer-Emmett-Teller surface area and apparent porosity. The release of Ca and P in simulated body fluid was monitored by X-ray fluorescence. The adsorption capacity and extended-release dosage of implants were investigated with ibuprofen, an anti-inflammatory drug, by UV-VIS spectroscopy. The highest adsorption efficiency and stability were obtained for sintered (S) (Hap-) and 20% gelatin (G) nanocomposite (Hap-20G-S) and bone parts coated with Hap-S and Hap-20G-S nanocomposite, respectively. The best results (high adsorption efficiency and slow release - low desorption capacity) were obtained for molded Hap-20G-S composite, without bone. In summary, the cattle bones with hydroxyapatite coatings show great promise in production of inexpensive and patient-specific bone implants.

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STUDIA UBB CHEMIA, Volume 63 (LXIII), No. 3, September 2018

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Published

2018-09-28

How to Cite

BARABÁS, R. ., RIGÓ, M. ., ENISZNÉ-BÓDOGH, M. ., MOISA, C. F. ., & CADAR, O. . (2018). PREPARATION AND CHARACTERIZATION OF HYDROXYAPATITE BASED NANO-COMPOSITE BIOMORPHIC IMPLANTS. Studia Universitatis Babeș-Bolyai Chemia, 63(3), 137–154. https://doi.org/10.24193/subbchem.2018.3.11