A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS

Authors

  • Claudiu N. LUNGU Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University; Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Romania. Email: lunguclaudiu5555@gmail.com. https://orcid.org/0000-0002-5416-3142
  • Csaba PAIZS Faculty of Chemistry and Chemical Engineering, Hungarian Line of Study, Babes-Bolyai University, Cluj Napoca, Romania. Email: csaba.paizs@ubbcluj.ro. https://orcid.org/0000-0002-7403-7098
  • Melinda Emese FÜSTÖS (LÁSZLÓ) Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: melinda.laszlo@ubbcluj.ro. https://orcid.org/0000-0001-9902-5651
  • Anamaria ORZA Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Corresponding author: lunguclaudiu5555@gmail.com. https://orcid.org/0000-0001-7865-4926
  • Mircea V. DIUDEA Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: diudea@chem.ubbcluj.ro. https://orcid.org/0000-0003-2556-6329
  • Ireneusz P. GRUDZINSKI Department of Applied Toxicology, Faculty of Pharmacy, Medical University of Warsaw, Poland. Email: ireneusz.grudzinski@wum.edu.pl. https://orcid.org/0000-0002-6113-1771

DOI:

https://doi.org/10.24193/subbchem.2019.2.42

Keywords:

molecular descriptors, pharmacophore, QSAR, continuous structures, toxicity, maximum recommended daily dose, dendrimers

Abstract

Polyethyleneimines (PEIs) and polyamidoamine dendrimers (PAMAM) are widely used as non-biological transporters in modern gene therapies. In this study, several zero-generation aromatic core “ZAC” dendrimers were computationally studied for predictive toxicity assessment. The chemical synthesis of the ZAC dendrimers was carried out using three different bromomethylbenzene derivatives as aromatic core and dialkanolamines as branching units with different carbon chain length. Quantitative structure-activity relationships (QSAR) and virtual high throughput toxicity screening (vHTTS) assays were applied on the synthesized zero generation dendrimers to evaluate their toxicities.

 

References

R. Hood, Developmental and reproductive toxicology: a practical approach, 3rd ed., CRC, Boca Raton, FL, 2011.

V.C. Arena; N.B. Sussman; S. Mazumdar; S. Yu; O.T. Macina; SAR QSAR Environ. Res., 2004,15, 1-18.

C. Hansch; A. Leo; S.B. Mekapati; A. Kurup; Biorg. Med. Chem., 2004, 12, 3391-3400.

T. Langer; G. Wolber; Pure. App. Chem., 2004, 76, 991-996.

M.E. Füstös; T.A. Sipos; M.V. Diudea; G. Katona; Croat. Chem. Acta, 2015, 88, 129-132.

M.V. Diudea; C.N. Lungu; C.L. Nagy; Molecules, 2018, 23, 2533.

C.N. Lungu; S. Ersali; B. Szefler; A. Pirvan-Moldovan; S. Basak; M.V. Diudea; Studia UBB, Chemia, 2017, 62, 197-204.

A. Vedani; M. Dobler; M. Smieško; Toxicol. Appl. Pharmacol., 2012, 261, 142-153.

A.J. Leo; C. Hansch; Perspect. Drug. Discov. Design, 1999,17, 1-25.

C.N. Lungu; M.V. Diudea; M.V. Putz; Int. J. Mol. Sci., 2017, 18, 1377.

S. Kim; E.E. Bolton; S.H. Bryant; J. Cheminform., 2011, 3, 26.

R. Perkins; H. Fang; W.D. Tong; W.J. Welsh; Environ. Toxicol. Chem., 2003, 22, 1666-1679.

C.N. Lungu; B.I. Bratanovici; M.M. Grigore; V. Antoci; I. Mangalagiu; Curr. Med. Chem., 2018, doi: 10.2174/0929867326666181220094229.

STUDIA UBB CHEMIA, Volume 64 (LXIV), No.2, Tome II, June 2019

Downloads

Published

2019-06-28

How to Cite

LUNGU, C. N. ., PAIZS, C. ., FÜSTÖS (LÁSZLÓ), M. E. ., ORZA, A. ., DIUDEA, M. V. ., & GRUDZINSKI, I. P. . (2019). A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS. Studia Universitatis Babeș-Bolyai Chemia, 64(2), 499–508. https://doi.org/10.24193/subbchem.2019.2.42

Issue

Volume 64, No. 2, Tome II, 2019

Section

Articles

License

Copyright (c) 2019 Studia Universitatis Babeș-Bolyai Chemia

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

1 2 3 > >> 

Similar Articles

<< < 11 12 13 14 15 16 17 18 19 20 > >> 

You may also start an advanced similarity search for this article.