A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS

Claudiu N.  LUNGU; Csaba  PAIZS; Melinda Emese  FÜSTÖS (LÁSZLÓ); Anamaria  ORZA; Mircea V.  DIUDEA; Ireneusz P.  GRUDZINSKI

doi:10.24193/subbchem.2019.2.42

A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS

Authors

Claudiu N. LUNGU Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University; Iuliu Hațieganu University of Medicine and Pharmacy Cluj-Napoca, Romania. Email: lunguclaudiu5555@gmail.com. https://orcid.org/0000-0002-5416-3142
Csaba PAIZS Faculty of Chemistry and Chemical Engineering, Hungarian Line of Study, Babes-Bolyai University, Cluj Napoca, Romania. Email: csaba.paizs@ubbcluj.ro. https://orcid.org/0000-0002-7403-7098
Melinda Emese FÜSTÖS (LÁSZLÓ) Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: melinda.laszlo@ubbcluj.ro. https://orcid.org/0000-0001-9902-5651
Anamaria ORZA Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Corresponding author: lunguclaudiu5555@gmail.com. https://orcid.org/0000-0001-7865-4926
Mircea V. DIUDEA Department of Chemistry, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Email: diudea@chem.ubbcluj.ro. https://orcid.org/0000-0003-2556-6329
Ireneusz P. GRUDZINSKI Department of Applied Toxicology, Faculty of Pharmacy, Medical University of Warsaw, Poland. Email: ireneusz.grudzinski@wum.edu.pl. https://orcid.org/0000-0002-6113-1771

DOI:

https://doi.org/10.24193/subbchem.2019.2.42

Keywords:

molecular descriptors, pharmacophore, QSAR, continuous structures, toxicity, maximum recommended daily dose, dendrimers

Abstract

Polyethyleneimines (PEIs) and polyamidoamine dendrimers (PAMAM) are widely used as non-biological transporters in modern gene therapies. In this study, several zero-generation aromatic core “ZAC” dendrimers were computationally studied for predictive toxicity assessment. The chemical synthesis of the ZAC dendrimers was carried out using three different bromomethylbenzene derivatives as aromatic core and dialkanolamines as branching units with different carbon chain length. Quantitative structure-activity relationships (QSAR) and virtual high throughput toxicity screening (vHTTS) assays were applied on the synthesized zero generation dendrimers to evaluate their toxicities.

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STUDIA UBB CHEMIA, Volume 64 (LXIV), No.2, Tome II, June 2019

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Published

2019-06-28

How to Cite

LUNGU, C. N. ., PAIZS, C. ., FÜSTÖS (LÁSZLÓ), M. E. ., ORZA, A. ., DIUDEA, M. V. ., & GRUDZINSKI, I. P. . (2019). A PREDICTIVE TOXICITY STUDY OF PEIs, PAMAM AND ZAC DENDRIMERS. Studia Universitatis Babeș-Bolyai Chemia, 64(2), 499–508. https://doi.org/10.24193/subbchem.2019.2.42