VINCRISTINE AFFECTS THE REDOX REACTIVITY OF HEMOGLOBIN

Victoria CÎRJEU; Cristina PUȘCAȘ; Radu SILAGHI-DUMITRESCU

doi:10.24193/subbchem.2021.2.28

Authors

Victoria CÎRJEU Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania.
Cristina PUȘCAȘ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania.
Radu SILAGHI-DUMITRESCU Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. *Corresponding author: rsilaghi@chem.ubbcluj.ro https://orcid.org/0000-0002-4625-6525

DOI:

https://doi.org/10.24193/subbchem.2021.2.28

Keywords:

vincristine, hemoglobin, autoxidation, nitrite, oxidative stress, nitrosative stress, UV-vis.

Abstract

The anticancer drug vincristine, known to act by inhibiting tubulin function in human cells, is shown to affect autoxidation rates in hemoglobin – either alone or under conditions where nitrite acts as an initiator in a nitrosative stress cascade. This behavior mirrors those observed by us with four other antitubulin agents - irinotecan, docetaxel, paclitaxel and vinorelbine.

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