SYNTHESIS OF Pt(II)-COMPLEXES WITH SYMMETRICAL AND UNSYMMETRICAL GLYOXIMES, THEIR PHYSICAL-CHEMICAL AND BIOLOGICAL STUDY

Csaba VÁRHELYI Jr.; Róbert TÖTÖS; Melinda SIMON-VÁRHELYI; Judit PAPP; Judith MIHÁLY; Raluca-Anca MEREU; Laura MARINCAS; János MADARÁSZ; György POKOL; Roland SZALAY; Maria TOMOAIA-COTIŞEL

doi:10.24193/subbchem.2022.4.21

SYNTHESIS OF Pt(II)-COMPLEXES WITH SYMMETRICAL AND UNSYMMETRICAL GLYOXIMES, THEIR PHYSICAL-CHEMICAL AND BIOLOGICAL STUDY

Authors

Csaba VÁRHELYI Jr. Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany J. str. 11, RO-400 028, Cluj-Napoca, Romania. csaba.varhelyi@ubbcluj.ro https://orcid.org/0000-0003-2938-4637
Róbert TÖTÖS Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany J. str. 11, RO-400 028, Cluj-Napoca, Romania. robert.totos@ubbcluj.ro https://orcid.org/0000-0003-1743-3905
Melinda SIMON-VÁRHELYI Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany J. str. 11, RO-400 028, Cluj-Napoca, Romania. melinda.varhelyi@ubbcluj.ro https://orcid.org/0000-0002-0300-3376
Judit PAPP Babeş-Bolyai University, Faculty of Biology and Geology, Mihail Kogălniceanu str. 1, RO-400084, Cluj-Napoca, Romania. judit.papp@ubbcluj.ro https://orcid.org/0000-0002-9192-9610
Judith MIHÁLY Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry, Magyar tudósok körútja 2, H-1117 Budapest, Hungary. mihaly.judith ttk.mta.hu
Raluca-Anca MEREU Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany J. str. 11, RO-400 028, Cluj-Napoca, Romania. raluca.mereu@ubbcluj.ro https://orcid.org/0000-0003-1643-4543
Laura MARINCAS Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany J. str. 11, RO-400 028, Cluj-Napoca, Romania. laura.marincas@ubbcluj.ro https://orcid.org/0000-0002-6736-2976
János MADARÁSZ Budapest University of Technology and Economics, Faculty of Chemical Technology and Biotechnology, Műegyetem rkp. 3, H-1111 Budapest, Hungary. madarasz@mail.bme.hu
György POKOL Budapest University of Technology and Economics, Faculty of Chemical Technology and Biotechnology, Műegyetem rkp. 3, H-1111 Budapest, Hungary. pokol@mail.bme.hu https://orcid.org/0000-0003-1597-9808
Roland SZALAY Eötvös Loránd University, Institute of Chemistry, Pázmány Péter sétány 1/A, H-1117, Budapest, Hungary. zalayr@chem.elte.hu https://orcid.org/0000-0003-3535-5365
Maria TOMOAIA-COTIŞEL Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Arany J. str. 11, RO-400 028, Cluj-Napoca, Romania. maria.tomoaia@ubbcluj.ro https://orcid.org/0000-0002-0995-3006

DOI:

https://doi.org/10.24193/subbchem.2022.4.21

Keywords:

Pt(II)-complexes, -dioxime, amine ligand, thermal properties, spectroscopy, AFM, antimicrobial activity

Abstract

A series of Pt-complexes of the type [Pt(DioxH)₂L₂], (DioxH= deprotonated diethyl-glyoxime, methyl-pentyl-glyoxime, methyl-propyl-glioxime, L=amine) were synthesized, described and characterized with thermoanalytical (TG-DTG-DTA), spectroscopical (FTIR, ESI-MS, UV-VIS and NMR), powder XRD and AFM methods. The biological activity, especially the antibacterial effect, was also studied. The complexes were tested against selected Gram-positive and Gram-negative bacteria. The thermoanalytical measurements revealed the stability of complexes until 200 °C, which then loose characteristic fragments of their ligands. The spectroscopic data are in accordance with the thermal properties of the samples, confirming their composition. The compounds exhibited antibacterial effect against the bacterial strain studied.

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STUDIA UBB CHEMIA, Volume 67 (LXVII), No. 4, December 2022

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Published

2022-12-30

How to Cite

VÁRHELYI Jr., C., TÖTÖS, R., SIMON-VÁRHELYI, M., PAPP, J., MIHÁLY, J., MEREU, R.-A., … TOMOAIA-COTIŞEL, M. (2022). SYNTHESIS OF Pt(II)-COMPLEXES WITH SYMMETRICAL AND UNSYMMETRICAL GLYOXIMES, THEIR PHYSICAL-CHEMICAL AND BIOLOGICAL STUDY. Studia Universitatis Babeș-Bolyai Chemia, 67(4), 315–335. https://doi.org/10.24193/subbchem.2022.4.21