Determination of Chemical Compositions, Antioxidant, DNA Cleavage and Binding Properties of Vincetoxicum Tmoleum Extract
DOI:
https://doi.org/10.24193/subbchem.2024.1.10Keywords:
Vincetoxicum tmoleum, antioxidant activity, DNA cleavage, HPLC-DADAbstract
Correction Note:
Article KILIÇKAYA SELVI, E., GÜLER, N., GÜVEN, S., & MAKBUL, S. (2024). Determination of Chemical Compositions, Antioxidant, DNA Cleavage and Binding Properties of Vincetoxicum Tmoleum Extract. Studia Universitatis Babeș-Bolyai Chemia, 69(1), 163–174, https://doi.org/10.24193/subbchem.2024.1.10 has been corrected in the Platform (Volume 69, No. 1, 2024 | Studia Universitatis Babeș-Bolyai Chemia).
Date: Wednesday, September 10, 2025 10:40 AM
Subject: Request for Article Correction - Request from Emine Kılıçkaya Selvi.
The changes include:
-References 34 and 43 was revised.
-Figure 1 and Table 1 was revised.
Other parts of the article were left untouched. No changes were made that would compromise the integrity and content of the article.
Editors’ Note: The article was corrected on 10.09.2025. The pdf file of the volume also includes a Corrigendum.
ABSTRACT. In the present study, phenolic compounds, antioxidant activities, DNA cleavage and binding effects of Vincetoxicum tmoleum (Vt) collected from west of Anatolia (Manisa city) were investigated. Antioxidant potentials of the extracts were characterized with their total phenolic and flavonoid contents, DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid), and FRAP (ferric reducing antioxidant power assay) tests. Besides, the DNA cleavage and binding features of V. tmoleum extract were studied using pBR322 DNA and CT-DNA, respectively. Phenolic compounds of the extract were analyzed by high performance liquid chromatography (HPLC-DAD). As a result, V. tmoleum methanol extract was found to have the high total phenolic and total flavonoid content and antioxidant effect. Strong positive correlations were also found between DPPH and TFC (r = 0.995; p < 0.01), and TPC (r = 0.989;p < 0.01), ABTS (r = 0.994;p < 0.01) and FRAP(r=0,995; p < 0.01). Methanol extract of V. tmoleum had large amounts of p-coumaric acid, vanillic acid and catechin. While V. tmoleum samples showed weak DNA cleavage activity, they showed DNA binding activity at 50 µM concentration, that is, the potential to be an intercalation agent in this concentration.
References
S. Liede-Schumann; U. Meve; Phytotaxa, 2018, 369, 129–184.
S. E. Sheeley; D. J. Raynal; Bull. Torrey Bot. Club, 1996, 123, 148–156.
M. A. Zaidi; Jr. S. A. Crow; J. Ethnop¬harmacol., 2005, 96, 331–334.
L. Q. Wang; J. H. Wang; Y. M. Shen; J. Zhou; Chin. Chem. Lett., 2007, 18, 1235–238.
I. Šliumpaitė; M. Murkovic; A. Zeb; P. R. Venskutonis; Ind. Crops Prod., 2013, 45, 74–82.
A. DiTommaso; F. M. Lawlor; S. J. Darbyshire; Can. J. Plant Sci., 2005, 85, 243–263.
S. Noorian; A. M. Sani; A. Yazdani; Asian J. Biol. Life Sci., 2015, 4(1), 35–38.
S. Nourian; A. M. Sani; E. Golmakani; P. Feizi; K. Roghani; Int. J. PharmTech Res., 2016, 9(3), 150–157.
M. Lavault; P. Richomme; J. Bruneton; Fitoterapia, 1999, 70, 216–220.
M. Lavault; P. Richomme; J. Bruneton; Pharm. Acta Helv., 1994, 68, 225–227.
R. Nowak; W. Kisiel; Fitoterapia, 2000, 71, 584–586.
U. Tanner; W. Wiegrebe; Arch. Pharm. (Weinheim), 1993, 326, 67–72.
D. Staerk; J. Christensen; E. Lemmich; J. Duus; C. E. Olsen; J. W. Jaroszewski; J. Nat. Prod., 2000, 63, 1584–1586.
D. Staerk; A. L. Lykkeberg; J. Christensen; B. A. Budnik; F. Abe; J. W. Jaroszewski; J. Nat. Prod., 2002, 65, 1299–1302.
M. A. Zaidi; S. A. Crow; Pak. J. Bot., 2012, 44(SI), 395–397.
C. Mogg; P. Petit; N. Cappuccino; T. Durst; C. McKague; M. Foster; J. E. Yack; J. T. Arnason; M. L. Smith; Biochem. Syst. Ecol., 2008, 36, 383–391.
D. M. Gibson; S. B. Krasnoff; J. Biazzo; L. Milbrath; J. Chem. Ecol., 2011, 37, 871– 879.
A. J. Shah; M. A. Zaidi; H. Sajjad; H. A. H. Gilani; Bangladesh J. Pharmacol., 2011, 6, 46–50.
A. Mansoor; M. A. Ibrahim; M. A. Zaidi; M. Ahmed; Bangladesh J. Pharmacol., 2011, 6, 51–54.
Z. Zahra; M. R. Khan; S. A. Shah; S. Maryam; M. Majid; T. Younis; M. Sajid; J. Ethnopharmacol., 2020, 252, 112565.
S. Güven; K. Coşkunçelebi; S. Makbul; Nord. J. Bot., 2021, 39(12), e03405.
S. Güzel; R. Pavela; A. İlçim; G. Kökdil; Marmara Pharm. J., 2017, 21(4), 872–880.
S. Guzel; Chem. Nat. Compd., 2020, 56(2), 202–206.
S. Güzel; R. Pavela; G. Kökdil; International Anatolian Academic Online Journal/ Health Science, 2015, 3(2), 1–9.
S. Guzel; M. Ulger; G. Kokdil; International Journal of Scientific and Technological Research, 2018, 4(3), 27–38.
S. Güzel; M. Ülger; G. Aslan; G. Kökdil; Marmara Pharm. J., 2018, 22(3), 365–373.
S. Güzel; M. Ülger; Y. Özay; Ö. Yumrutaş; İ. Bozgeyik; Ö. Sarıkaya; Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi, 2019, 9(3), 367–375.
E. Altundağ; M. Öztürk; Procedia Soc. Behav. Sci., 2011, 19, 756–777.
K. Browicz; Asclepiadaceae, in Flora of Turkey and the East Aegean Islands, Vol. 6, P.H. Davis, Ed.; Edinburgh University Press, Edinburgh, UK, 1978, pp 163-174.
S. Güven; S. Makbul; K. Coşkunçelebi; Recep Tayyip Erdoğan Üniversitesi Fen ve Mühendislik Bilimleri Dergisi, 2021, 2 (2), 1–12.
C. Rice-Evans; N. Miller; G. Paganga; Trends Plant Sci., 1997, 2(4), 152–159.
S. Kawanishi; Y. Hiraku; Curr. Med. Chem. Anticancer Agents, 2004, 4(5), 415–419.
Y. Shen; X. Song; L. Li; J. Sun; Y. Jaiswal; J. Huang; C. Liu; W. Yang; L. Williams; H. Zhang; Y. Guan; Biomed Pharmacother, 2019, 111, 579-587.
A. Magiera; J. Kołodziejczyk-Czepas; a M.A. Olszewsk. Molecules, 2025, 30(3), 467. https://doi.org/10.3390/molecules30030467.
N. S. Fursa; V. I. Litvinenko; L. E. Belyaeva; Khlmiya Prirodnykh Soedinenii, 1977, 3, 416.
G. Slapšytė; V. Dedonytė; A. Adomėnienė; J. R Lazutka; J. Kazlauskaitė; O. Ragažinskienė; P. R. Venskutonis; Food Chem. Toxicol., 2019, 134, 110815.
V. L. Singleton; R. Orthofer; R. M. Lamuela Raventós; Methods Enzymol., 1999, 299, 152-178.
M. Marcucci; R. Woisky; A. Salatino; Mensagem Doce, 1998, 46, 3-9.
P. Molyneux; Warasan Songkhla Nakharin, 2004, 26, 211–219.
I. F. F. Benzie; J. J. Strain; Methods Enzymol., 1999, 299, 15–27.
Z. Lu; G. Nie; P. S. Belton; H. Tang; B. Zhao; Neurochem. Int., 2006, 48, 263–274.
T. Keleş; B. Barut; A. Özel; Z. Biyiklioglu; Dyes Pigments, 2019, 164, 372.
F. Ayaz; E. Köngül Şafak; K. Erkan Turkmen; G. Şeker Karatoprak; H. Katırcıoğlu; N. Küçükboyacı; J. Food Meas. Charact. 2021, 15, 4267–4276.
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