SYNTHESIS OF NEW 5-(CHROMENE-3-YL)METHYLENE-2,4-THIAZOLIDINEDIONES

Authors

  • Cristina NASTASĂ Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: cmoldovan@umfcluj.ro. https://orcid.org/0000-0002-5803-6108
  • Brînduşa TIPERCIUC Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: btiperciuc@umfcluj.ro. https://orcid.org/0000-0002-6732-5147
  • Laurian VLASE Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy; Department of Clinical Pharmacology and Pharmacokinetics. Email: laurian.vlase@umfcluj.ro. https://orcid.org/0000-0002-0664-3387
  • Adrian PÎRNĂU National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: adrian.pirnau@itim-cj.ro. https://orcid.org/0000-0002-2313-9350
  • Ovidiu ONIGA Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ooniga@umfcluj.ro. https://orcid.org/0009-0003-4539-8905

Keywords:

chromone; thiazolidinedione; α-bromoalkylarylketones

Abstract

With the aim of developing new biologically active compounds, a series of new N-substituted 5-(chromene-3-yl)methylene-2,4- thiazolidinediones 3-12 has been synthesized. The first step was the condensation of different chromone-3-carbaldehydes with 2,4-thiazolidinedione, followed by the reaction with various α-bromoalkylarylketones. The structures of all new compounds were confirmed by elemental analysis, mass spectra and 1H NMR studies.

References

S.S. Tang, A. Apisarnthanarak, L. Yang Hsu, Adv Drug Deliver Rev, 2014, 78, 3.

G. Na, W. Zhang, S. Zhou, H. Gao, Z. Lu, X. Wu, R. Li, L. Qiu, Y. Cai, Z. Yao, Mar Pollut Bull, 2014, 84, 70.

D.O. Ogbolu, M. A. Webber, Int J Antimicrob Ag, 2014, 43, 412.

L.Y. Hsu, T.Y. Tan, V.H. Tam, A. Kwa, D.A. Fisher, T.H. Koh, Antimicrob Agents Chemother, 2010, 54(3), 1173.

WHO Library Cataloguing-in-Publication Data. Antimicrobial resistance: global report on surveillance. WHO Press, World Health Organization, 20 Avenue Appia, 1211 Geneva 27, Switzerland.

F.L. Gouveia, R.M.B. de Oliveira, T.B. de Oliveira, I.M. da Silva, S.C. do Nascimento, K.X.F.R. de Sena, J.F.C. de Albuquerque, Eur J Med Chem, 2009, 44(5), 2038.

D.A. Heerdind, L.T. Christmann, T.J. Clark, D.J. Holmes, S. F. Rittenhouse, D.T. Takata, J.W. Venslavsky, Bioorg Med Chem Lett, 2003, 13, 3771.

V.V. Mulwad, A.A. Mir, H.T. Parmar, Ind J Chem, 2009, 48B, 137.

K.R. Alagawadi, S.G. Alegaon, Arab J Chem, 2011, 4(4), 465.

X.F. Liu, C.J. Zheng, L.P. Sun, X.K. Liu, H.R. Piao. Eur J Med Chem, 2011, 46(8), 3469.

K. Hatzade, V. Taile, P. Gaidhane, V. Ingle Turk J Chem, 2010, 34, 241.

T.E. Ali, M.A. Ibrahim, J Brazil Chem Soc, 2010, 21, 1007.

C.N. Khobragade, R. Bodade, M.S. Shinde, D. Jaju, R.B. Bhosle, B.S. Dawane, J Enzym Inhib Med Ch, 2008, 23, 341.

S.B. Kale, B.K. Karale, J Het Chem, 2007, 44, 289.

C. Nastasă, M. Duma, C. Marie, D. Scherman, B. Tiperciuc, O. Oniga, Dig J Nanomater Bios, 2013, 8(3), 1079.

O. Bozdağ-Dündar, B. Evranos, N. Daş-Evcimen, M. Sarıkaya, R. Ertan, Eur J Med Chem, 2008, 43(11), 2412.

STUDIA UBB CHEMIA, Volume 60 (LX), No. 4, September 2015

Downloads

Published

2015-12-30

How to Cite

NASTASĂ, C. ., TIPERCIUC, B. ., VLASE, L. ., PÎRNĂU, A. ., & ONIGA, O. . (2015). SYNTHESIS OF NEW 5-(CHROMENE-3-YL)METHYLENE-2,4-THIAZOLIDINEDIONES. Studia Universitatis Babeș-Bolyai Chemia, 60(4), 239–246. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8511

Issue

Volume 60, No. 4, 2015

Section

Articles

License

Copyright (c) 2015 Studia Universitatis Babeș-Bolyai Chemia

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

Most read articles by the same author(s)

1 2 > >>