SYNTHESIS OF NEW 5-(CHROMENE-3-YL)METHYLENE-2,4-THIAZOLIDINEDIONES

Authors

  • Cristina NASTASĂ Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: cmoldovan@umfcluj.ro. https://orcid.org/0000-0002-5803-6108
  • Brînduşa TIPERCIUC Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: btiperciuc@umfcluj.ro. https://orcid.org/0000-0002-6732-5147
  • Laurian VLASE Department of Pharmaceutical Technology and Biopharmaceutics, Faculty of Pharmacy, Iuliu Hațieganu University of Medicine and Pharmacy; Department of Clinical Pharmacology and Pharmacokinetics. Email: laurian.vlase@umfcluj.ro. https://orcid.org/0000-0002-0664-3387
  • Adrian PÎRNĂU National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: adrian.pirnau@itim-cj.ro. https://orcid.org/0000-0002-2313-9350
  • Ovidiu ONIGA Department of Pharmaceutical Chemistry, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ooniga@umfcluj.ro. https://orcid.org/0009-0003-4539-8905

Keywords:

chromone; thiazolidinedione; α-bromoalkylarylketones

Abstract

With the aim of developing new biologically active compounds, a series of new N-substituted 5-(chromene-3-yl)methylene-2,4- thiazolidinediones 3-12 has been synthesized. The first step was the condensation of different chromone-3-carbaldehydes with 2,4-thiazolidinedione, followed by the reaction with various α-bromoalkylarylketones. The structures of all new compounds were confirmed by elemental analysis, mass spectra and 1H NMR studies.

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STUDIA UBB CHEMIA, Volume 60 (LX), No. 4, September 2015

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Published

2015-12-30

How to Cite

NASTASĂ, C. ., TIPERCIUC, B. ., VLASE, L. ., PÎRNĂU, A. ., & ONIGA, O. . (2015). SYNTHESIS OF NEW 5-(CHROMENE-3-YL)METHYLENE-2,4-THIAZOLIDINEDIONES. Studia Universitatis Babeș-Bolyai Chemia, 60(4), 239–246. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8511

Issue

Volume 60, No. 4, 2015

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Articles

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