HETEROCYCLES 50. SYNTHESIS AND CHARACTERIZATION OF NEW 2-PHENYLAMINOTHIAZOLE DERIVED MANNICH BASES BY BIOCATALYTIC MULTICOMPONENT REACTIONS

Denisa  LEONTE; Robert  TŐTŐS; Valentin ZAHARIA

doi:10.24193/subbchem.2019.2.15

Authors

Denisa LEONTE Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: leonte.denisa@umfcluj.ro. https://orcid.org/0000-0001-5442-8182 (unauthenticated)
Robert TŐTŐS Biocatalysis and Biotransformations Research Group, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: robert.totos@ubbcluj.ro. https://orcid.org/0000-0003-1743-3905 (unauthenticated)
Valentin ZAHARIA Department of Organic Chemistry, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. *Corresponding author: vzaharia@umfcluj.ro. https://orcid.org/0000-0001-7083-7680 (unauthenticated)

DOI:

https://doi.org/10.24193/subbchem.2019.2.15

Keywords:

thiazole, Mannich base, lipase, multicomponent reactions

Abstract

In this work we describe the synthesis and characterization of new Mannich bases derived from 2-phenylaminothiazole, by applying the trimolecular condensation of thiazole aldehydes with aniline and acetone, catalyzed by lipase B from Candida antarctica. The target compounds were obtained with 68-76% yields, in mild and eco-friendly reaction conditions. The new heterocyclic Mannich bases were characterized by melting points, ¹H NMR, ¹³C NMR and MS spectrometry.

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HETEROCYCLES 50. SYNTHESIS AND CHARACTERIZATION OF NEW 2-PHENYLAMINOTHIAZOLE DERIVED MANNICH BASES BY BIOCATALYTIC MULTICOMPONENT REACTIONS

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