SYNTHESIS AND ANTIOXIDANT CAPACITY OF (CHLOROBENZYLIDENE)HYDRAZINYL-THIAZOLES

Authors

  • Adriana GROZAV Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: adriana.ignat@umfcluj.ro. https://orcid.org/0000-0001-5800-0896
  • Daniela HANGANU Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: dhanganu@umfcluj.ro. https://orcid.org/0000-0002-5407-8001
  • Ovidiu CRIȘAN Faculty of Pharmacy, “Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: dhanganu@umfcluj.ro.
  • Dan Ioan PORUMB Faculty of Chemistry and Chemical Engineering, “Babeș-Bolyai” University, Cluj-Napoca, Romania. Email: ioan.porumb@ubbcluj.ro. https://orcid.org/0000-0001-6388-2686
  • Castelia CRISTEA Faculty of Chemistry and Chemical Engineering, “Babeș-Bolyai” University, Cluj-Napoca, Romania. Email: castelia.cristea@ubbcluj.ro. https://orcid.org/0000-0003-1138-2596

DOI:

https://doi.org/10.24193/subbchem.2019.2.43

Keywords:

synthesis, thiazoles, antioxidant capacity, DPPH, FRAP

Abstract

2-(chlorobenzilidene)hydrazinyl-thiazole derivatives were conveniently prepared by Hantzsch reaction protocol, starting with thiosemicarbazone and ethyl 2-bromo-3-oxo-3-phenylpropanoate. Their antioxidant capacity was screened by electron transfer based assays. The results of both DPPH (1,1-Diphenyl-2-picrylhydrazyl) free radical scavenging, as well as Ferric Ion Reducing Antioxidant Power (FRAP) assay, indicated antioxidant capacity for the tested hydrazone derivatives. At the concentration of 9.5 µg/mL, the DPPH radical scavenging activity of ethyl 2-(2-(3-chlorobenzylidene)hydrazinyl)-4-phenylthiazole-5-carboxylate was found to be more than 93%.

References

R. Mishra, P. K. Sharma, P. K. Verma, I. Tomer, G. Mathur, P. K. Dhakad, J. Heterocycl. Chem., 2017, 54(4), 2103.

A. Grozav, L. I. Găină, V. Pileczki, O. Crisan, L. Silaghi-Dumitrescu, B. Therrien, V. Zaharia, I. Berindan-Neagoe, Int. J. Mol. Sci., 2014,15(12), 22059.

A. Grozav, B. Stancu, C. Boari, F. Chirila, N. Fit, C. Cristea, Studia UBB Chemia, 2017, 62(2), 365.

A.C. Cosma, A. Ignat, I.C. Tarca, V. Zaharia, S. D. Bolboaca, L. Jantschi, Rev.Chim., 2018, 69 (4), 777.

B. Brem, E.Gal, L. Găină, L.Silaghi-Dumitrescu, E. Fischer-Fodor, C. I. Tomuleasa, A. Grozav, V. Zaharia, L. Filip, C. Cristea, Int. J. Mol. Sci., 2017, 18(7), 1365.

A.T. Mbaveng, A. Grozav Ignat, B. Ngameni, V. Zaharia, B.T. Ngadjui, V. Kuete; BMC Pharmcol. Toxicol., 2016, 17 (3).

M. Sabou, A. Grozav, L. M. Junie, M. Flota, V. Zaharia, C. Cristea, Studia UBB Chemia, 2016, 61(3),117.

A. Grozav, V. Zaharia, C. Cristea, N. I. Fit, Studia UBB Chemia, 2015, 60(3), 283.

B. Bream, E. Gal, C. Cristea, L. Gaina, A. Grozav, V. Zaharia, L. Silaghi-Dumitrescu, Studia UBB Chemia, 2015, 60(2), 371.

M. A. Pop, T. C. Drugan, A. Grozav, B. Domokos, A. Urda, C. M. Pop, Studia UBB Chemia, 2014, 59(3), 119.

A. Ignat (Grozav), L. Gaina, V. Kuete, L. Silaghi-Dumitrescu, T. Efferth, V. Zaharia, Molecules, 2013, 18(4), 4679.

V. Zaharia, A. Ignat (Grozav), B. Ngameni, V. Kuete, M. L. Moungang, C. N. Fokunang, M. Vasilescu, N. Palibroda, C. Cristea, L. Silaghi-Dumitrescu, B. T. Ngadju, Med. Chem. Res., 2013, 22, 5670.

A. Ignat (Grozav), T. Lovasz, M. Vasilescu, E. F. Fodor, C. B. Tatomir, C. Cristea, L. Silaghi-Dumitrescu, V. Zaharia, Archiv Der Pharmazie, 2012, 345 (7), 574.

A. Cozma, L. Vlase, A. Ignat (Grozav), V. Zaharia, S. Gocan, C. Marutoiu, A. Fodor, Rev. Chim., 2012, 63(7), 651.

A. Cozma, L. Vlase, A. Ignat, (Grozav), V. Zaharia, S. Gocan, N. Grinberg, J. L. Chromatogr. Relat. Technol., 2012, 35(1-4), 590.

V. Zaharia, A. Ignat (Grozav), N. Palibrod, B. Ngameni, V.Kuete, C. N. Fokunang, M. L. Moungang, B. T. Ngadjui, Eur. J. Med. Chem., 2010, 45(11), 5080.

A. Ignat (Grozav), V. Zaharia, C. Mogoşan, N. Palibroda, C. Cristea, L. Silaghi-Dumitrescu, Farmacia, 2010, 58 (3), 290.

M. Abdel-Maksouda, U.M. Usama, O. Chang-Hyun, Bioorg. Med. Chem., 2019, 27(10), 20141.

A. Grozav, I. D. Porumb, L. I. Găină, L. Filip, D. Hanganu, Molecules, 2017, 22(2), 260.

S. Cetean, T. Ciuleanu, D. C. Leucuta, C. Cainap, A. M. Constanti, I. Cazacu, S. Cainap, A. Gherman, L. Oprean, A. Hangan, R. Oprean, J. BUON, 2015, 20(6),1623.

Yong-Jin Wu, Five-Membered Ring Systems: With N and S Atom in Progress in heterocyclic chemistry, Ed. G. W. Gribble, J. A. Joule, ISHC Elsevier, 2015, Vol. 27, chapter 5.5, pp. 287-303.

D. Huang, B. Ou, R. L. Prior, J. Agric. Food Chem., 2005, 53, 1841-1856.

Downloads

Published

2019-06-28

How to Cite

GROZAV, A. ., HANGANU, D. ., CRIȘAN, O. ., PORUMB, D. I. ., & CRISTEA, C. . (2019). SYNTHESIS AND ANTIOXIDANT CAPACITY OF (CHLOROBENZYLIDENE)HYDRAZINYL-THIAZOLES. Studia Universitatis Babeș-Bolyai Chemia, 64(2), 409–516. https://doi.org/10.24193/subbchem.2019.2.43

Issue

Section

Articles

Most read articles by the same author(s)

1 2 3 > >> 

Similar Articles

<< < 13 14 15 16 17 18 19 > >> 

You may also start an advanced similarity search for this article.