FROM PHYTOCHEMISTRY TO METABOLOMICS: EIGHT DECADES OF RESEARCH IN PLANT AND FOOD SCIENCE

Authors

DOI:

https://doi.org/10.24193/subbchem.2019.4.15

Keywords:

Phytochemistry, Metabolomics, Analytical platform

Abstract

Phytochemistry represents a large interdisciplinary research area which apply the chemical knowledge in plant biology, biochemistry and physiology. Since centuries, the technology related to the isolation and characterization of phytochemicals (plant secondary metabolites) developed gradually towards a holistic approach of omics’ technology, as part of the systems biology concept. This review underlines the scientific progress during the last eight decades, from classical phytochemistry to metabolomics, applied on plants and food and reflects not only the role of phytochemicals as key-molecules with essential roles in plants and with great benefits on animal and human health, but also their involvement in plant chemotaxonomy, food technology and authenticity. First, a selection of the major groups of phytochemicals and their main bioresources. The metabolomic technology is presented, as a high-throughput analytical platform to identify, by untargeted or targeted techniques, the fingerprint or key metabolites of a specific pathway in plants or for authentication of a food matrix. Updated literature data are presented, including a summary of eight decades of achievements of the research group related to Chemistry and Biochemistry of Natural Products at the University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca, now celebrating 150 years of existence.

References

R. Wayne; Plant Cell Biology (2nd Ed), Ed Elsevier, 2019, 411-423.

J. Buckingham; Dictionary of Natural Products. Abingdon: Taylor & Francis, USA, 1993.

F. Scossa; M. Benina; S. Alseekh; Y. Zhang; A.R. Fernie; Planta Med., 2018, 84, 855-887.

J. Arnason; R.Mata; J.T.Romeo; Phytochemistry of Medicinal Plants. Springer Science & Business Media, 2013.

E.T. Wurtzel; T.M. Kutchan; Science, 2016, 353, 1232-1236.

M.S. Meskin; Phytochemicals in Nutrition and Health, 2002, CRC Press.

O. Fiehn; Plant Mol. Biol., 2002, 48, 155-171.

G.J. Patti; O.Yanes; G.Siuzdak; Nature Reviews, 2012, 13, 263-269.

U. Roessner; D.A. Dias; (Eds.), Metabolomics Tools for Natural Product Discovery, Methods and Protocols, Humana Press, 2013.

W. Weckwerth; Metabolomics: methods-protocols in Methods in molecular biology, Humana Press, 2007.

A. Zhang; H. Sun; P. Wang; Y. Han; X. Wang; The Analyst, 2012, 137, 293-300.

S.D. Johanningsmeier; G.K. Harris; C.M. Klevorn; Annual Review of Food Science and Technology, 2016, 7, 413-438.

D.D. Marshall; R. Powers; (2017). Progress in Nuclear Magnetic Resonance Spectroscopy, 2017, 100, 1-16.

C. E. Turi; Jamie Finley; Paul R. Shipley; Susan J. Murch; P. N. Brown; J. Nat. Prod., 2015, 78, 953-966.

P. Mendes; Brief. Bioinform., 2002, 3, 134-145.

Dr. Duke's Phytochemical and Ethnobotanical Databases, https://phytochem.nal.usda.gov/phytochem/plants.

L.W. Sumner; P.Mendes; R.A. Dixon; Phytochemistry, 2003, 62, 817-836.

F. Tugizimana; L.Piater; I.Dubery; South Afr. J.Sci., 2013, 109,1-11.

R. Hall; M. Beale; O. Fiehn; N.Hardy; L.Sumner; R.Bino; Plant Cell, 2002, 14, 1437-1440.

R.D. Hall (Ed.), Annual Plant Reviews; Wiley-Blackwell Publishing, Oxford, UK, 2011, 43, 448-465.

A.R. Fernie; Funct Plant Biol, 2003, 30,111-120.

J. Kopka; A. Fernie; W. Weckwerth; Y. Gibon; M. Stitt; Genome Biol., 2004, 5, 109–117.

W. Weckwerth (ed.); The Handbook of Plant Metabolomics, Wiley-Blackwell, Guenter Kahl, 2013.

R.N. Trethewey; Curr. Opin. Plant Biol., 2004, 7, 196-201.

T. Tenenboim; Y. Brotman; Trends in Plant Science, 2016, 21, 781-792.

T. Garnatje et al.; Trends in Plant Science, 2017, 22, 187-198.

A. Piasecka; P. Kachlick; M. Stobiecki; Int. J. Mol. Sci., 2019, 20, 379-397.

R. Kumar; A. Bohra; A.K.Pandey; M.K.Pandey; A.Kumar; Frontiers in Plant Sci., 2017, 8, 1302-1309.

C. Deborde; J.X. Fontaine; D. Jacob; A. Botana; V. Nicaise; F. Richard-Forget; S. Lecomte; C. Decourtil; K. Hamade; F. Mesnard; A. Moing; R. Molinié; Metabolomics, 2019, 15, 28-36.

D.S. Wishart; Trends Food Sci.Technol., 2008, 19, 482-493.

J.M. Cevallos-Cevallos; J.I. Reyes-De-Corcuera; E. Etxeberria; M.D. Danyluk; G.E. Rodrick; Trends Food Sci.Technol, 2009, 20, 557-566.

A. Scalbert; L. Brennan; O. Fiehn; T. Hankemeier; B.S. Kristal; B. van Ommen; Metabolomics, 2009, 5, 435-458.

J. Rubert; M. Zachariasova; J. Hajslova; Food Additives and Contaminants- Part A Chemistry, Analysis, Control, Exposure and Risk Assessment, 2015, 32, 1685-1708.

U. Thissen; L. Coulier; K.M. Overkamp; J. Jetten; B.J.C. van der Werff; T.Van de Ven; M.J. Van der Werf; Food Quality and Preference, 2011, 22, 499-512.

C. Diez-Simon; R. Mumm; R.D. Hall; Metabolomics, 2019, 15, 41-49.

K. Bohme; P. Calo-Mata; J. Barros-Velazquez; I. Ortea; Trends Anal. Chem., 2019, 110, 221-234.

G. Ulrich-Merzenich; H. Zeitler; D. Jobst; D.Panek; H.Vetter; H.Wagner; Phytomedicine, 2007, 14, 70-82.

C. Bodea; Tratat de Biochimie vegetală, Ed.Academiei RSR, vol. I-VI, 1964-1984.

G. Neamtu; V.Tămaş; Pigmenţi carotenoidici şi metaboliţi, Ed.Ceres, Bucureşti, 1986.

C. Bodea; I. Silberg; Adv. Heterocyclic Chem., 1968, 9, 321-332.

C. Socaciu; Chimia Alimentelor, Ed. AcademicPres, Cluj-Napoca, 2017, 126 pag.

C. Socaciu; A. Pintea; in Seabuckthorn, A Multipurpose Wonder Plant ed. V. Singh, Indus International, India, 2006, pp. 342-360.

A. Bunea; C. Socaciu; A. Pintea; Not. Bot. Horti. Agrobo, 2014, 42, 310-324.

C. Socaciu (ed.); Food Colorants: Chemical and Functional Properties, CRC Press-Taylor and Francis Group, New York, 2008, 633 pp.

C. Socaciu, H.A. Diehl; Instruments to analyse food colors, in Handbook of Food Analysis Instruments, S. Otles Ed., CRC Press-Taylor and Francis Group, New York, 2009, chapter 1.

C. Socaciu; Agrofood Industry Hi-tech, 2009, 20, 43-46.

V.S. Chedea; S.I. Vicaş; C. Socaciu; T. Nagaya; H. J. Oduor Ogola; K. Yokota; K. Nishimura; M.Jisaka; Lipoxygenase-Quercetin Interaction: A Kinetic Study Through Biochemical and Spectroscopy Approaches, Biochemical Testing, 2012, InTech Publ, pp. 29.

C. Socaciu; in Alimentaţia funcţională cu componente bioactive naturale în sindromul metabolic, Ed. Eurostampa, Timişoara, 2009, pp. 95-127.

C. Socaciu; Bull. USAMV-AGR, 2002, 58, 22-29.

S.I. Vicas; D. Rugină; C. Socaciu; in Phytochemicals as Nutraceuticals- Global Approaches to Their Role in Nutrition and Health, InTech Publ., 2012, pp. 21.

Z. M. Diaconeasa; A. D. Frond; I. Stirbu; D. Rugina; C. Socaciu; Anthocyanins-Smart Molecules for Cancer Prevention, Intech Publ., 2018, chapter 5.

C. Socaciu; Bull. USAMV-AGR, 2006, 62, 352-359.

C. Coman; O. D. Rugină; C. Socaciu; Not. Bot. Horti. Agrobio., 2012, 40, 314-325.

A.N. Boca; D. Tataru; A. Buzoianu; C. Pincelli; C. Socaciu; Not. Bot. Horti. Agrobio., 2014, 42, 1-8.

C. Socaciu; 1st Int. Congr. Danube Reg. Bot. Gardens, Arad, 7-9.09. 2017.

C. Socaciu; Symp. Rom. Acad., University A.I Cuza, Iaşi, 15.10. 2010.

D. Pătraş; C.V. Moraru; C. Socaciu; Screening of bioactive compounds synthesized by microalgae: a progress overview on extraction and chemical analysis, Studia UBB Chemia, 2018, 63, 21-35.

D. Pătraş; C.V. Moraru; C. Socaciu; Bull. USAMV -FST, 2019, 76, 1-15.

C. Socaciu; F. Ranga; F. Fetea; D. Leopold; F. Dulf; R. Parlog; Czech J. Food Sci., 2009, 27, S70-S75.

C. Socaciu; R. Pop; F.Ranga; F. Fetea; Int. Conf. Rom. Soc. Biochemistry and Molecular Biology, Oradea, 5-6.06.2014.

C. Socaciu; 6th Int. Congr. Pigments in Food, Budapest, 2010.

C. Socaciu; Fl.Ranga; F. Fetea; F.Dulf;, 5th Int. Conf. Plant Metabolomics, Yokohama, Japan, 2008.

C.Socaciu; Fl.Ranga; F. Fetea; Metabomeeting, Lyon, 2008.

T. E. Coldea; E. Mudura; C. Socaciu; Advances in Distilled Beverages Authenticity and Quality Testing, InTechopen Publ. 2017, chapter 6.

C. Socaciu; C. Moraru; D. Patras 4th North and East Eur. Congr. on Food, Kaunas, 11-13.09. 2017.

A. Pintea; A. Marpeau; M. Faye; C. Socaciu; M. Gleizes; Phytochem. Anal., 2001, 12, 293-298.

F. Dulf; C. Socaciu; C. Bele; Bull. USAMV-VM, 2005, 61, 388-393.

C. Bodea; A.G. Andrewes; G. Borch; S. Liaaen-Jensen; Phytochemistry, 1978, 17, 2037-2045.

C.Bodea; Pure Appl. Chem., 1969, 20, 517-527

A. Bunea; A. Pintea; S. Andrei; A. Lujerdean; C. Socaciu; Bull. USAMV-Zoo, 2006, 62, 282-286.

T.E. Rusu; C. Socaciu; M. Parv; D.C. Vodnar; Not. Bot. Horti. Agrobo., 2011, 39, 109-116.

Bunea; D. O. Rugină; A.M. Pintea; Z. Sconţa; C.I. Bunea; C. Socaciu;, Not. Bot. Horti. Agrobio., 2011, 39, 70-76.

F. Dulf; S. Andrei; A. Bunea; C. Socaciu; Chem. Papers, 2012, 66, 925-934.

L. Holonec; F.Ranga; D. Crainic; A. Truţa; C. Socaciu; Not. Bot. Horti. Agrobio., 2012, 40, 99-105.

T. Hodisan; C. Socaciu; I. Ropan; G. Neamtu; J. Pharm. Biomed. Anal., 1997, 25, 256-262.

E.A. Pop; Z.M. Diaconeasa; F.Fetea; A. Bunea; F. Dulf; A. Pintea; C.Socaciu; Bull. USAMV-FST, 2015, 72, 169-175.

C. Socaciu; S.Drăgan; F.Ranga; F. Fetea; D.Preda; 3rd Int. Conf. Polyphenols and Health, Kyoto, Japan, 2007.

F.V. Dulf; I. Oroian; D.C. Vodnar; C. Socaciu; A. Pintea; Molecules, 2013, 18, 11768-11785.

A. Bunea; M. Andjelkovic; C. Socaciu; O. Bobis; M. Neacsu; R. Verhé; J. Van Camp; Food Chemistry, 2008, 108, 649-656.

V.S. Chedea; C. Braicu; C. Socaciu; Food Chemistry, 2010, 121, 132-139.

S. Vicas; J. Prokisch; D. Rugina; C. Socaciu; Not. Bot. Horti. Agrobo., 2009, 37, 112-116.

C. Socaciu; R. Jessel; H.A. Diehl; Chem. Phys Lipids, 2000, 106, 79-88.

C. Socaciu, S. Haertel; H. A. Diehl; Spectrochimica Acta, part A, 1999, 55, 2289-2297.

I. Lancrajan, H. A. Diehl; C. Socaciu; M. Engelke; M. Zorn-Kruppa; Chem. Phys. Lipids, 2001, 112, 1-10.

A. Pintea; C. Socaciu; H. A. Diehl; Biophys. Chem., 2005, 118, 7-14.

A. Pintea; C. Bele; S. Andrei; C. Socaciu; Acta Biol. Szegediensis, 2003, 47, 37-40.

A. Pintea; A. Varga; P. Stepnowski; C. Socaciu; M. Culea; H.A. Diehl; Phytochemical Analysis, 2005, 16, 188-195.

M. Andjelkovic; J. Van Camp; B. De Meulenaer; G. Depaemelaere; C. Socaciu; M. Verloo ; R. Verhe; Food Chemistry, 2006, 98, 23-31.

D. Rugină; S. Vicaş; C. Momeu; C. Socaciu; Chem. Listy, 2008, 99, 1234-1235.

D.C. Vodnar, J. Venus ; R. Schneider ; C. Socaciu; Chem. Eng. & Technol., 2010, 33, 468-474.

D.C. Vodnar; C. Socaciu; International J. Food Sci. & Technol., 2010, 45, 2345-2351.

A. Pintea; D. Rugina; R. Parlog; C. Socaciu; Rom. Biotechnol. Lett., 2010, 15, 4964-4978.

S. Vicas; V. Chedea; C.Socaciu; J. Food Biochem., 2011, 35, 613-627.

S. Vicaş; D. Rugina; C. Socaciu; J. Med. Plant Res., 2011, 5, 2237-2244.

A. Pintea; D. Rugina; A. Bunea; R. Pop; C. Socaciu, J. Food Comp. Anal., 2011, 24, 830-836.

A. Chis; F. Fetea; H. Matei; C. Socaciu; Not. Bot. Horti. Agrobo., 2011, 39, 99-104.

A. Pintea; D. Rugina; R. Pop; A. Bunea; C. Socaciu; H.A. Diehl; J. Ocular Pharmacol. & Ther., 2011, 27, 315-321.

D. Rugină; Z. Sconţa; L. Leopold; A. Pintea; A. Bunea; C. Socaciu; J. Med. Food, 2012, 15, 700-706.

D.C. Vodnar; C. Socaciu; Chem. Central J., 2012, 61-69.

Bunea; D. Rugină; Z. Sconţa; R. M. Pop; A. Pintea; C. Socaciu; F.Tăbăran; C. Grootaert; K.Struijs; J. VanCamp; Phytochemistry, 2013, 95, 436-444.

C. Coman; L.F. Leopold; O.D. Rugină; L.Barbu-Tudoran; N. Leopold; M. Tofană; C. Socaciu; J. Nanopart. Res., 2013, 16, 2158-2167.

D.C. Vodnar; C. Socaciu; LWT-Food Sci.Technol., 2014, 57, 406-411.

D.Preda; I. Berindan Neagoe; O.Balacescu; 3rd Int. Conf. on Polyphenols and Health, Kyoto, Japan, 2007.

Z. Diaconeasa; L. Leopold; D. Rugina; C. Socaciu; Int. J. Mol. Sci., 2015, 16, 2352-2365.

D. Rugină; Z. Diaconeasa; C. Coman; A. Bunea; C. Socaciu; A. Pintea; Oxidative Med. Cellular Longevity, 2015, 1-10.

F.V. Dulf; D.C. Vodnar; C. Socaciu; Food Chemistry, 2016, 209, 27-36.

Z. Diaconeasa; H. Ayvaz; D. Ruginǎ; L. Leopold; A. Stǎnilǎ; C. Socaciu; Plant Foods for Human Nutr., 2017, 72, 404-410.

C. Pop; A. M. Rotar; L. Salanţă; S. Socaci; F.Ranga; C. Socaciu;, Bull. USAMV-FST, 2015, 72, 91-98.

M. Neacsu; C. Socaciu; M. Tamas; C. Blidar; Bull. USAMV-AGR, 2002, 58, 37-43.

M. Neacsu; S.Vicas; C. Socaciu; Bull. USAMV-AGR, 2008, 65, 310-315

V. Chedea; C. Echim; C. Socaciu; J. Food Biochem., 2011, 35, 92-108.

S. Zavoi; F. Fetea; F. Ranga; R. Pop; A. Baciu; C. Socaciu; Not. Bot. Horti. Agrobio., 2011, 39, 82-89.

V.S. Chedea; P. Kefalas; C. Socaciu; Journal of Food Biochemistry, 2010, 34, 101-110.

S. Vicas; D. Rugina; L. Leopold; A.Pintea A.; C. Socaciu; Not. Bot. Horti. Agrobio., 2011, 39, 48-57.

S.A. Socaci; C. Socaciu; C. Mureşan; A. Fǎrcaş; M.Tofanǎ; S. Vicaş; A. Pintea; Phytochem. Anal., 2014, 25, 165-169.

S.A. Socaci; C. Socaciu; M. Tofana; V. Rati; A. Pintea; Phytochem. Anal., 2013, 24, 319-328.

S.I. Vicas; A.C.Teusdea; M. Carbunar; S. Socaci; C. Socaciu; Plant Foods Human Nutr., 2013, 68, 313-321.

R.M. Pop; Y. Weesepoel; C. Socaciu; A. Pintea; J.P. Vincken; H.Gruppen; Food Chemistry, 2014, 42, 1-8.

M. Badalica-Petrescu; S. Dragan; F. Ranga; F. Fetea; C. Socaciu; Not. Bot. Horti. Agrobio., 2014, 42, 9-18.

R. M. Pop; C. Socaciu; A. Pintea; A.D. Buzoianu; M.D. Sanders; H. Gruppen; J.P. Vincken; Phytochem. Anal., 2013, 24, 484-492.

R. M. Pop; A. Buzoianu; V. Rati; C. Socaciu; Not. Bot. Horti. Agrobio., 2014, 42, 545-550.

F.Bunghez; A. M. Rotar; D.C. Vodnar; G.M. Cătunescu; C. Socaciu; Rom. Biotechnol. Lett., 2016, 21, 1-15.

F.V. Dulf; D.C. Vodnar; E.H. Dulf; Z. Diaconeasa; C. Socaciu; LWT-Food Sci. Technol., 2018, 87, 241-249.

C.Socaciu; F.Ranga; F. Fetea; 5th Int. Conf. on Plant Metabolomics Pacifico, Yokohama, Japan, 2008.

C. Moraru; K. Skjanes; D. Patras; C. Socaciu; C.J.J.Spetz;, 18th Int. Symposium on Carotenoids, Luzern, 9-14 July 2017.

A.G. Lazar; F.Romanciuc; M.A. Socaciu; C. Socaciu; Bull. USAMV-FST, 2015, 72, 103-115.

M. Andjelković; J. Van Camp; C. Socaciu; R. Verhe; Commun. Agric. Appl. Biol. Sci., 2006, 71, 19-23.

C. Socaciu; F. Ranga; H. A. Diehl; Bull. USAMV-AGR, 2005, 61, 295-300.

M. Andjelkovic; J Van Camp; M. Pedra; K. Renders; C. Socaciu; R. Verhe;

J. Agric. Food Chem., 2008, 56, 5181-5187.

F. Dulf; C. Socaciu; C. Bele; A. Pintea; M. Unguresan; Chem. Listy, 2008, 102, s265–s309.

M. Streza; D. Dadarlat; C. Socaciu; C. Bele; F. Dulf; V. Simon; Food Biophys., 2009, 4,147-150.

L.F. Leopold; H.A. Diehl; C. Socaciu; Bull. USAMV-AGR, 2006, 62, 288-293.

F. Dulf; M. Unguresan; D. Vodnar; C. Socaciu; Not. Bot. Horti. Agrobo., 2010, 38, 91-97.

L.F. Leopold; N. Leopold; H.A. Diehl; C. Socaciu; Spectroscopy-Int J., IOS Press, 2011, 112.

L.F. Leopold; N. Leopold; H.A. Diehl; C. Socaciu; Food Anal. Meth., 2012, 5, 405-407.

T.E. Coldea; C. Socaciu; F. Fetea; F. Ranga; R.M. Pop; M. Florea; Not. Bot. Horti. Agrobio., 2013, 41, 143-149.

R. Banc; F. Loghin; D. Miere; F. Fetea; C. Socaciu; Not. Bot. Horti. Agrobio., 2014, 42, 556-564.

S. I. Vicas; A. C. Teusdea; M. Carbunar; C. Socaciu; Rom. Biotech. Lett., 2015, 20,1067-1075.

L. Cuibus; D. Dadarlat; M. Streza; F.V. Dulf; Z.Diaconeasa; C. Socaciu; J. Therm. Anal. Calorim., 2017, 127, 1193-1200.

L. Cuibus; R. Maggio; V. Mureșan; Z. Diaconeasa; O.L. Pop; C. Socaciu; Bull. USAMV-FST, 2015, 72, 70-76.

E. Mudura; T.E. Coldea; C. Socaciu; F. Ranga; C. Pop; A.M. Rotar; A. Pasqualone; J. Serbian Chem. Soc., 2018, 83, 19-30.

Downloads

Published

2019-12-30

How to Cite

SOCACIU, C. . (2019). FROM PHYTOCHEMISTRY TO METABOLOMICS: EIGHT DECADES OF RESEARCH IN PLANT AND FOOD SCIENCE. Studia Universitatis Babeș-Bolyai Chemia, 64(4), 205–224. https://doi.org/10.24193/subbchem.2019.4.15

Issue

Section

Articles

Most read articles by the same author(s)

Similar Articles

<< < 3 4 5 6 7 8 9 10 11 > >> 

You may also start an advanced similarity search for this article.