PREPARATION AND CHARACTERIZATION OF ATORVASTATIN-LOADED POLYVINYLPIRROLIDONE-BASED ELECTROSPUN MICROFIBROUS MATS

Authors

  • Emőke RÉDAI „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania.
  • Izabella RÁDULY „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania.
  • Zoltán-István SZABÓ „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Industry and Management department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania. https://orcid.org/0000-0002-4625-6525
  • Adriana CIURBA „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania.
  • Nicoleta TODORAN „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania. https://orcid.org/0000-0002-4625-6525
  • Paula ANTONOAEA „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania. * Corresponding author: paula.antonoaea@umfst.ro
  • Robert-Alexandru VLAD „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania.
  • Orsolya PÉTERFI „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and cosmetology department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania. https://orcid.org/0000-0002-4625-6525
  • Emese SIPOS „George Emil Palade” University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Industry and Management department, Gh. Marinescu street no. 38, 540142 Targu Mures, Romania.

DOI:

https://doi.org/10.24193/subbchem.2021.2.25

Keywords:

atorvastatin, electrospinning, PVP, microfibrous mats.

Abstract

The aim of this experimental work was the enhancement of water solubility of the lipid lowering drug, atorvastatin, by embedding it in polymer based micro-sized fibers, prepared by electrospinning. Characterization of the fibrous mats included morphological investigations, determination of drug content, disintegration time, small volume dissolution- and DSC studies. The electrospinning process was continuous without droplet formation. The obtained fibers were homogenous, continuous filaments with smooth surfaces. Average fiber diameters were slightly above 1 µm, while disintegration of fiber mats upon contact with water was almost instantaneous (three to ten seconds). Dissolution of the lipid lowering drug was almost complete, when using a solution feed rate of 1 mL/h.

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STUDIA UBB CHEMIA, Volume 66 (LXVI), No. 2, June 2021

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Published

2021-06-30

How to Cite

RÉDAI, E., RÁDULY, I., SZABÓ, Z.-I., CIURBA, A., TODORAN, N., ANTONOAEA, P., … SIPOS, E. (2021). PREPARATION AND CHARACTERIZATION OF ATORVASTATIN-LOADED POLYVINYLPIRROLIDONE-BASED ELECTROSPUN MICROFIBROUS MATS. Studia Universitatis Babeș-Bolyai Chemia, 66(2), 287–297. https://doi.org/10.24193/subbchem.2021.2.25

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Volume 66, No. 2, 2021

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