CURCUMIN-WHEY PROTEIN SOLID DISPERSION SYSTEM WITH IMPROVED SOLUBILITY AND CANCER CELL INHIBITORY EFFECT

Levente RÁCZ; Georgeta SERBAN; Flavia MARTIN; Xenia FILIP; Alexandra CIORÎȚĂ; Sebastian PORAV; Ioana GROSU; Paula BULIERIS; Csaba-Pal RÁCZ; Maria TOMOAIA-COTISEL; Irina KACSÓ

doi:10.24193/subbchem.2021.3.13

CURCUMIN-WHEY PROTEIN SOLID DISPERSION SYSTEM WITH IMPROVED SOLUBILITY AND CANCER CELL INHIBITORY EFFECT

Authors

Levente RÁCZ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania.
Georgeta SERBAN University of Oradea, Faculty of Medicine and Pharmacy, 29 Nicolae Jiga str., RO-410028, Oradea, Romania. https://orcid.org/0000-0002-2926-0995
Flavia MARTIN National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania.
Xenia FILIP National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0001-6441-3793
Alexandra CIORÎȚĂ National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0003-2991-3957
Sebastian PORAV National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0003-4238-0083
Ioana GROSU National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0003-1174-2790
Paula BULIERIS National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0001-9819-9393
Csaba-Pal RÁCZ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0001-7981-7678
Maria TOMOAIA-COTISEL Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0002-0995-3006
Irina KACSÓ National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. *Corresponding author: irina.kacso@itim-cj.ro https://orcid.org/0000-0003-1039-0543

DOI:

https://doi.org/10.24193/subbchem.2021.3.13

Keywords:

curcumin, whey protein concentrate, complexation, enhanced solubility, anticarcinogenic effect.

Abstract

he solid dispersion system containing a high amount of the natural compound curcumin was prepared with whey protein concentrate by spray-drying method in 5:1 molar ratio. X-ray powder diffraction and DSC techniques show the formation of the solid dispersion system in amorphous state, and the presence of weak hydrogen bond type interactions between the components was established by FTIR analysis. SEM images show highly homogeneous donut-like spherical microparticles morphology for the system. The solubility of curcumin from the system was enhanced compared to practically insoluble raw curcumin, reaching a value of 70 µg/mL in aqueous buffer solution at pH=8 similar with intestinal environment. The synthesized material had better effects against skin melanoma cells, compared to lung adenocarcinoma cells, but in both cases the effect was promising, and through further and more complex analyses the antitumoral potential of CUC-WPC_SD could be exploited.

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STUDIA UBB CHEMIA, Volume 66 (LXVI), No. 3, September 2021

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Published

2021-09-30

How to Cite

RÁCZ, L., SERBAN, G., MARTIN, F., FILIP, X., CIORÎȚĂ, A., PORAV, S., … KACSÓ, I. (2021). CURCUMIN-WHEY PROTEIN SOLID DISPERSION SYSTEM WITH IMPROVED SOLUBILITY AND CANCER CELL INHIBITORY EFFECT. Studia Universitatis Babeș-Bolyai Chemia, 66(3), 209–224. https://doi.org/10.24193/subbchem.2021.3.13