CURCUMIN-WHEY PROTEIN SOLID DISPERSION SYSTEM WITH IMPROVED SOLUBILITY AND CANCER CELL INHIBITORY EFFECT

Authors

  • Levente RÁCZ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania.
  • Georgeta SERBAN University of Oradea, Faculty of Medicine and Pharmacy, 29 Nicolae Jiga str., RO-410028, Oradea, Romania. https://orcid.org/0000-0002-2926-0995
  • Flavia MARTIN National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania.
  • Xenia FILIP National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0001-6441-3793
  • Alexandra CIORÎȚĂ National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0003-2991-3957
  • Sebastian PORAV National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0003-4238-0083
  • Ioana GROSU National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0003-1174-2790
  • Paula BULIERIS National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. https://orcid.org/0000-0001-9819-9393
  • Csaba-Pal RÁCZ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0001-7981-7678
  • Maria TOMOAIA-COTISEL Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0002-0995-3006
  • Irina KACSÓ National Institute of Research&Development for Isotopic and Molecular Technologies, 67-103 Donath str., RO-400293 Cluj-Napoca, Romania. *Corresponding author: irina.kacso@itim-cj.ro https://orcid.org/0000-0003-1039-0543

DOI:

https://doi.org/10.24193/subbchem.2021.3.13

Keywords:

curcumin, whey protein concentrate, complexation, enhanced solubility, anticarcinogenic effect.

Abstract

he solid dispersion system containing a high amount of the natural compound curcumin was prepared with whey protein concentrate by spray-drying method in 5:1 molar ratio. X-ray powder diffraction and DSC techniques show the formation of the solid dispersion system in amorphous state, and the presence of weak hydrogen bond type interactions between the components was established by FTIR analysis. SEM images show highly homogeneous donut-like spherical microparticles morphology for the system. The solubility of curcumin from the system was enhanced compared to practically insoluble raw curcumin, reaching a value of 70 µg/mL in aqueous buffer solution at pH=8 similar with intestinal environment. The synthesized material had better effects against skin melanoma cells, compared to lung adenocarcinoma cells, but in both cases the effect was promising, and through further and more complex analyses the antitumoral potential of CUC-WPC_SD could be exploited.

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Published

2021-09-30

How to Cite

RÁCZ, L., SERBAN, G., MARTIN, F., FILIP, X., CIORÎȚĂ, A., PORAV, S., … KACSÓ, I. (2021). CURCUMIN-WHEY PROTEIN SOLID DISPERSION SYSTEM WITH IMPROVED SOLUBILITY AND CANCER CELL INHIBITORY EFFECT. Studia Universitatis Babeș-Bolyai Chemia, 66(3), 209–224. https://doi.org/10.24193/subbchem.2021.3.13

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