LIPASE CATALYZED PARALLEL KINETIC RESOLUTION OF IBUPROFEN

Botond  NAGY; Mădălina Elena  MOISĂ; Alina  FILIP; László Csaba  BENCZE

Authors

Botond NAGY Faculty of Chemistry and Chemical Engineering, Biocatalysis and Biotransformation Research Centre, Babeş-Bolyai University, Cluj-Napoca, Romania. Corresponding author: mtosa@chem.ubbcluj.ro.
Mădălina Elena MOISĂ Faculty of Chemistry and Chemical Engineering, Biocatalysis and Biotransformation Research Centre, Babeş-Bolyai University, Cluj-Napoca, Romania. Corresponding author: mtosa@chem.ubbcluj.ro. https://orcid.org/0000-0003-3215-5210
Alina FILIP Research Center for Enzymology and Applied Biocatalysis, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Emaill: alina.filip@ubbcluj.ro. https://orcid.org/0000-0001-6820-9204
László Csaba BENCZE Biocatalysis and Biotransformations Research Center, Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, Cluj-Napoca, Romania. Email: cslbencze@chem.ubbcluj.ro. https://orcid.org/0000-0003-0956-9749

Keywords:

lipase, Ibuprofen, enzymatic kinetic resolution, stereoselectivity

Abstract

A series of commercially available lipases in various solvents using several alcohols as nucleophiles were studied for the stereoselective esterification of ibuprofen and alcoholysis of ibuprofen esters respectively. Novel methods were developed for the stereoselective synthesis of both enantiomers of the target compound. The (S)-selective alcoholysis and (R)-selective hydrolysis in a parallel kinetic resolution procedure in presence of lipase from Mucor miehei as catalyst were performed.

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