SCREENING OF BIOACTIVE COMPOUNDS SYNTHESIZED BY MICROALGAE: A PROGRESS OVERVIEW ON EXTRACTION AND CHEMICAL ANALYSIS

Authors

  • D. PATRAS Faculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine; R&D Center for Applied Biotechnology in Diagnosis and Molecular Therapy, BIODIATECH-Proplanta Cluj-Napoca, Romania. Corresponding author: csocaciu@proplanta.ro.
  • C. V. MORARU R&D Center for Applied Biotechnology in Diagnosis and Molecular Therapy, BIODIATECH-Proplanta Cluj-Napoca, Romania. Corresponding author: csocaciu@proplanta.ro.
  • Carmen SOCACIU R&D Center for Applied Biotechnology in Diagnosis and Molecular Therapy, BIODIATECH-Proplanta, Cluj-Napoca, Romania. Email: csocaciu@proplanta.ro. https://orcid.org/0000-0002-7352-5057

DOI:

https://doi.org/10.24193/subbchem.2018.1.02

Keywords:

microalgae, bioactive compounds, cell disruption, extraction, spectrometry, chromatography

Abstract

Considering the high biodiversity of microalgae and their important impact on economy and ecological balance, new screening techniques are needed for their phenotypic characterization and efficient valorization of bioactive components. This represents one the key purpose of the emerging bioeconomy concept, involving new biorefinery technologies coupled with advanced analytical tools. The article presents an overview of the recent extraction and chemical techniques used to recover, separate and characterize the main bioactive molecules (lipids and fatty acids, carbohydrates, proteins and mycosporine-like amino acids chlorophylls and carotenoid pigments) syntesized by microalgae, considering their interesting applications in food, pharmaceutical and cosmetic industries. Special focuses will be directed towards the cell disintegration and extraction procedures, identification and quantification of main metabolites by advanced analytical techniques.

References

E. Christaki, E. Bonos, I. Giannenas, P. C. Florou-Paneri, Journal of the Science of Food and Agriculture, 2013, 93(1), 5.

M. Greque de Morais, B. da Silva Vaz, E. Greque de Morais, J.A. Vieira Costa, BioMed Research International, 2015, ID 835761, 1.

A. Villarruel-Lopez, F. Ascencio, K.Nuno, Polish Journal Of Food And Nutrition Sciences , 2017, 67, 251

K.H. Wiltshire, M. Boersma, A. Möller, H. Buhtz, Aquatic Ecology, 2000, 34, 120.

S.M. Mostafa, Plant Science, 2012, chapter 12.

K.H.M. Cardozo, T. Guaratini, M.P. Barros, V.R. Falcão, A.P. Tonon, N.P. Lopes, S. Campos, M.A. Torres, A.O. Souza, P. Colepicolo, E. Pinto, Comparative Biochemistry and Physiology, 2007, C 146, 60.

E. Gunerken, E. D’Hondt, M.H.M. Eppink, L. Garcia-Gonzalez, K. Elst, R.H. Wijffels, Biotechnology Advances, 2015, 33(2), 243.

A.G. Waghmare, M.K. Salve, J.G. LeBlanc, S.S. Arya, Bioresources and Bioprocessing, 2016, 3, 16.

D.W. Templeton, M. Quinn, S. Van Wychen, D. Hyman, L.M.L. Laurens, Journal of Chromatography A, 2012, 1270, 225.

Z. Cheng-Wu, O. Zmora, R. Kopel, A. Richmond, Aquaculture, 2001, 195, 35.

Z. Cohen, M. Reungjitchachawali, W. Siangdung, M. Tanticharoen, Journal of Applied Phycology, 1993, 24, 312.

C. Safi, A.V. Ursu, C. Laroche, B. Zebib, O. Merah, P.Y. Pontalier, C. Vaca-Garcia, Algal Research, 2014, 3, 61.

A.Z. Mustopa, R. Isworo, M. Nurilmala, D. Susilaningsih, Annales Bogorienses, 2016, 20(2), 47.

C. Schulze, M. Wetzel, J. Reinhardt, M. Schmidt, L. Felten, S. Mundt, Journal of Applied Phycology, 2016, 28, 2719.

C.A. Llewellyn, R.L. Airs, Marine Drugs, 2010, 8, 1273.

J.I. Carreto, M.O. Carignan, N.G Montoya, Marine Biology, 2005, 146, 237.

Y. Li, F. Ghasemi Naghdi, S. Garg, T.C. Adarme-Vega, K.J. Thurecht, W.A. Ghafor, S. Tannock, P.M. Schenk, Microbial Cell Factories, 2014, 13(1), 1.

S.S. Suh, J. Hwang, M. Park, H.H. Seo, H.S. Kim, J.H Lee, S.H. Moh, T.K. Lee, Marine Drugs, 2014, 12(10), 5174.

M. Henriques, A. Silva, J. Rocha, Extraction and quantification of pigments from a marine microalga: a simple and reproducible method, Communicating Current Research and Educational Topics and Trends in Applied Microbiology, Formatex, Spain, Vol. 2, 2007, 586.

A. Ilavarasi, D. Pandiaraj, D. Mubarakali, M.H. Ilyas , N. Thajuddin, Pakistan Journal of Biological Sciences, 2012, 15, 883.

S.M. Abdo, E. Ahmed, S. Abo El-Enin, R.S. El Din, G. El Diwani, G. Ali, Journal of Algal Biomass Utilization, 2014, 5(3), 23.

C. Hu, M. Li, J. Li, Q. Zhu, Z. Liu, World Journal of Microbiology and Biotehnology, 2008, 24, 1209.

Y. Jiang, K.W. Fan, R.T.Y. Wong, F. Chen, Journal of Agricultural and Food Chemistry, 2004, 52(5),1196.

J. Maligan, A. Saksony, V. Widayanti, Conference Proceeding, 2011.

A.P. Carvalho, F.X. Malcata, Marine Biotechnology, 2005, 7(4), 381.

N. Sato, M. Tsuzuki, A. Kawaguchi, Biochimica et Biophysica Acta, 2003, 1633(1), 35.

E. Ryckebosch, K. Muylaert, I. Foubert, Journal of the American Oil Chemists' Society, 2012, 89, 189.

E.C. Carballo-Cárdenas, P.M. Tuan, M. Janssen, R.H. Wijffels, Biomolecular Engineering, 2003, 20(4-6), 139.

T. Řezanka, L. Nedbalová, L. Procházková, K. Sigler, Phytochemistry, 2014, 100, 34.

E. da Costa, J. Silva, S. Hoffman Mendonça, M.H. Abreu, M.R. Domingues, Marine Drugs, 2016, 14(101), 1.

S. Ramaraj, J.S. Ki, A Review of the Biological Activities of Microalgal Carotenoids and Their Potential Use in Healthcare and Cosmetic Industries, Marine Drugs, 2018, 16, article 26.

C. Grosso, P. Valentão, F. Ferreres, P. Andrade, Marine Drugs, 2015, 13, 3184.

B. Tartarotti, R. Sommaruga, Archiv für Hydrobiologie, 2002, 154(4), 691.

K. Skjånes, C. Rebours, P. Lindblad, Critical Reviews in Biotechnology, 2013, 33(2), 195.

A. Jayshree, N. Thangaraju, Journal of Algal Biomass Utilization, 2014, 5, 61

D. Mouna, H. Bilel, M.Barkallah, et al., Bioresource Technology , 2018, 249, 510

E. Gunerken, E. D’Hondt, M.H.M. Eppink, L. Garcia-Gonzalez, K. Elst, R.H. Wijffels, Biotechnology Advances, 2015, 33(2), 243.

C.W. Yong, L. H. Yong, Applied Sciences-Basel, 2018, 8, article 26

M.Stramarkou, S.Papadaki, K. Kyriakopoulou et al, J. Applied Phycology, 2017, 29, 2947.

J.A. Gerde, M. Montalbo-Lomboy, L. Yao, D. Grewell, T. Wang, Bioresource Technology, 2012, 125, 175.

H. Zheng, J. Yin, Z. Gao, H. Huang, X. Ji, C. Dou, Applied Biochemistry and Biotechnology, 2011, 164, 1215.

J.Y. Lee, C. Yoo, S.Y. Jun, C.Y. Ahn, H.M. Oh, Bioresource Technology, 2010, 101(1), S75.

C. Eing, M. Goettel, R. Straessner, C. Gusbeth, W. Frey, IEEE Transactions on Plasma Science, 2013, 41(10), 2901.

S. Papadaki, K. Kyriakopoulou, K. Magdalini, IOSR Journal of Environmental Science, Toxicology and Food Technology, 2017, 10, 53.

H.G. Gerken, B. Donohoe, E.P. Knoshaug, Planta, 2013, 237(1), 239.

J. Asma, R. Brandon, H. Soleiman et al., Biomedical Journal, et al. 2017, 40, 339.

J. Azmir, I.S.M. Zaidul, M.M. Rahman, K.M. Sharif, A. Mohamed, F. Sahena, M.H.A. Jahurul, K. Ghafoor, N.A.N. Norulaini, A.K.M. Omar, Journal of Food Engineering, 2013, 117(4), 426.

A.C. Guedes, M.S. Giao, A.A. Matias, A.V.M. Nunes, M.E. Pintado, C.M.M. Duarte, F.X. Malcata, Journal of Food Engineering, 2013, 116, 478.

J. Pan, T. Muppaneni, Y. Sun, H.K. Reddy, J. Fu, X. Lu, S. Deng, Fuel, 2016, 178, 49.

F. Adam, M. Abert-Vian, G. Peltier, F. Chemat, Bioresource Technology, 2012, 114(5), 457.

S. Santoyo, M. Plaza, L. Jaime, E. Ibanez, G. Reglero, F.J. Senorans, Journal of Agricultural and Food Chemistry, 2010, 58, 8522.

D. Martin-Creuzburg, P. Merkel, Journal Plankton Research, 2016, 38(4), 865.

H.K. Lichtenthaler, C. Buschmann, Chlorophylls and carotenoids: measurement and characterization by UV-VIS spectroscopy, Current Protocols in Food Analytical Chemistry, John Wiley & Sons, Inc., 2001, UNIT F4.3.

A.Bertoli, B. Ruffoni, L. Pistelli, L. Pistelli, Analytical methods for the extraction and identification of secondary metabolite production in ‘In Vitro’ Plant Cell Cultures, Bio‑Farms for Nutraceuticals, Springer US, 2010, Chapter 19.

C. Moraru, K. Skjanes, D. Patras, C. Socaciu, CJJ Spetz, Proc. 18th Int. Symp. On Carotenoids, Basel, 9-14 July 2017 (poster presentation).

I. Lang, L. Hodac, T. Friedl, I. Feussner, BMC Plant Biology, 2011, 11, 124.

D. Barbano, R. Diaz, L. Zhang, T. Sandrin, H. Gerken, T. Dempster, PLOS One, 2015, 10(8).

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Published

2018-03-30

How to Cite

PATRAS, D. ., MORARU, C. V. ., & SOCACIU, C. . (2018). SCREENING OF BIOACTIVE COMPOUNDS SYNTHESIZED BY MICROALGAE: A PROGRESS OVERVIEW ON EXTRACTION AND CHEMICAL ANALYSIS. Studia Universitatis Babeș-Bolyai Chemia, 63(1), 21–35. https://doi.org/10.24193/subbchem.2018.1.02

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