COPPER(II) COMPLEXES WITH NEW N-SUBSTITUTED SULFONAMIDES – SYNTHESIS, CRYSTAL STRUCTURE AND EVALUATION OF THE NUCLEASE ACTIVITY

Authors

  • Andreea BODOKI Department of General and Inorganic Chemistry, Faculty of Pharmacy, UMF Iuliu Hatieganu, 400010 Ion Creanga, Cluj-Napoca, Romania. *Corresponding author: abota@umfcluj.ro https://orcid.org/0000-0001-7323-7293
  • Gloria ALZUET-PIÑA Department of Inorganic Chemistry, Faculty of Pharmacy, University of Valencia, 46100 Burjassot, Valencia, Spain https://orcid.org/0000-0003-0003-0413
  • Joaquín BORRÁS Department of Inorganic Chemistry, Faculty of Pharmacy, University of Valencia, 46100 Burjassot, Valencia, Spain
  • Tamara TOPALĂ Department of General and Inorganic Chemistry, Faculty of Pharmacy, UMF Iuliu Hatieganu, 400010 Ion Creanga, Cluj-Napoca, Romania https://orcid.org/0000-0001-8390-6403
  • Adriana HANGAN Department of General and Inorganic Chemistry, Faculty of Pharmacy, UMF Iuliu Hatieganu, 400010 Ion Creanga, Cluj-Napoca, Romania https://orcid.org/0000-0002-0944-3161
  • Gheorghe BORODI Department of Molecular and Biomolecular Service, National Institute for Research and Development for Isotopic and Molecular Technologies, 67-103 Donat, Cluj-Napoca, Romania https://orcid.org/0000-0003-4915-4169
  • Luminița OPREAN Department of General and Inorganic Chemistry, Faculty of Pharmacy, UMF Iuliu Hatieganu, 400010 Ion Creanga, Cluj-Napoca, Romania

DOI:

https://doi.org/10.24193/subbchem.2020.1.05

Keywords:

Cu(II) complexes, N-substituted sulfonamides, X-ray diffraction, nuclease activity

Abstract

Binary Cu(II) complexes of two new N-substituted sulfonamides, N-(pyridin-2-yl-methyl)biphenyl-4-sulfonamide (HL1) and N-bis-(pyridin-2-yl-methyl)biphenyl-4-4’-sulfonamide (H2L2), have been synthesized and characterized by X-ray diffraction, spectroscopic and electrochemical techniques. The structure of complex [Cu(L1)2] consists of a discrete monomeric Cu(II) species stabilized by π-π stacking interactions involving the pyridyl and phenyl rings of the coordinated ligands. In contrast, in the case of complex [Cu(L2)]n, each symmetrical  sulfonamide structure coordinates two Cu(II) ions, giving rise to a polymeric chain. Upon coordination, CuN4 chromophores with the N-pyrydil atoms in trans position are generated, and the coordination geometry of both complexes can be best described as highly distorted square-planar. The ability of complex [Cu(L1)2] to promote DNA cleavage with ascorbate activation was also evaluated; the complex has a moderate nuclease activity, being able to partially cleave supercoiled DNA to nicked circular and linear DNA. We herein also report the evaluation of the nuclease activity of complex Cu2(N-(pyridin-2-yl)biphenyl-4-sulfonamidate)4, previously characterized in terms of structure by our group.

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Published

2020-03-20

How to Cite

BODOKI, A., ALZUET-PIÑA, G., BORRÁS, J., TOPALĂ, T., HANGAN, A., BORODI, G., & OPREAN, L. (2020). COPPER(II) COMPLEXES WITH NEW N-SUBSTITUTED SULFONAMIDES – SYNTHESIS, CRYSTAL STRUCTURE AND EVALUATION OF THE NUCLEASE ACTIVITY. Studia Universitatis Babeș-Bolyai Chemia, 65(1), 55–69. https://doi.org/10.24193/subbchem.2020.1.05

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