EXAMINATION OF (PHENOTHIAZINYL)VINYL-PYRIDINIUM DYE’S CAPACITY OF INTERACTION WITH DNA

Bianca STOEAN; Luiza GAINA; Emese GAL; Castelia CRISTEA; Tamas LOVASZ; Luminita SILAGHI-DUMITRESCU

doi:10.24193/subbchem.2021.02.05

Authors

Bianca STOEAN Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. *Corresponding author: sba2488@chem.ubbcluj.ro
Luiza GAINA Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0002-1328-0107 (unauthenticated)
Emese GAL Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0003-4324-0787 (unauthenticated)
Castelia CRISTEA Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0003-1138-2596 (unauthenticated)
Tamas LOVASZ Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0003-2923-7442 (unauthenticated)
Luminita SILAGHI-DUMITRESCU Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0001-8800-4839 (unauthenticated)

DOI:

https://doi.org/10.24193/subbchem.2021.02.05

Keywords:

cyanine dyes, phenothiazine, DNA binding, association constant.

Abstract

The interaction of (E)-4-(2-(7-bromo-10-ethyl-10H-phenothiazin-3-yl)vinyl)-1-methylpyridin-1-ium (PVP) dyes with calf-thymus DNA was examined by spectrophotometric UV-vis absorption/emission titration and competitive ethidium bromide displacement. The association constant values were situated in 10⁶ M^-1 range, typical to cationic dyes containing the monocyanine chromophore system. The variation of the counterion of the cationic PVP dye from iodide to tetrafluoroborate produced dissimilarities in the interaction pattern with DNA. The PVP iodide competitively displaced the ethidium bromide (EB) from the EB-DNA system, thus suggesting the intercalation ability of the dye, while the PVP tetrafluoroborate did not supported the intercalation of the dye.

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EXAMINATION OF (PHENOTHIAZINYL)VINYL-PYRIDINIUM DYE’S CAPACITY OF INTERACTION WITH DNA

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