SYNHESIS AND INVESTIGATIONS OF γ-L-GLUTAMYL-CYCLOHEXYL AMIDE AND ITS TRANSITION METAL COMPLEXES

Authors

  • Carmen SACALIS Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. carmen.sacalis@ubbcluj.ro https://orcid.org/0000-0003-3140-4174
  • Sara JAHIJI University of Tetova, Faculty of Natural Sciences and Mathematics, Bldv.Ilinden, nn, 1200 Tetova, Republic of North Macedonia.
  • Alexandra AVRAM Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos str., RO-400028, Cluj-Napoca, Romania. alexandra.avram@ubbcluj.ro

DOI:

https://doi.org/10.24193/subbchem.2022.4.22

Keywords:

L-glutamic acid, glutamyl amides, metal complexes, thermal behavior

Abstract

A new route to obtain by regioselective acylation of cyclohexyl amine using N-phthaloyl-L-glutamic anhydride, followed by hydrolysis of phthaloyl group with hydrazine hydrate was performed in order to prepare γ-L-glutamyl-cyclohexyl amide. This one was used as ligand for a novel series of metal transition complexation like Cu(II), Co(II) and Ni(II). The ligand and its metal complexes were characterized via their spectral and thermogravimetric analysis. The thermal stability of the compounds was discussed in the 20-8000C temperature range. In all these complexes, the γ-L-glutamyl amide act as a bidentate ligand with coordination involving the carboxylate group and the nitrogen atom belonging to the amino group of glutamic acid fragment. The results indicate that their stability range obeys the Irving-Williams series.

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Published

2022-12-30

How to Cite

SACALIS, C., JAHIJI, S., & AVRAM, A. (2022). SYNHESIS AND INVESTIGATIONS OF γ-L-GLUTAMYL-CYCLOHEXYL AMIDE AND ITS TRANSITION METAL COMPLEXES. Studia Universitatis Babeș-Bolyai Chemia, 67(4), 337–352. https://doi.org/10.24193/subbchem.2022.4.22

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