Electrochemical Characterization and DNA Interaction Studies of a Novel Copper Schiff Base Complex: Insights From Cyclic Voltammetry and Molecular Docking

Chahinaz ZOUBEIDI; Ali OURARI; Elhafnaoui LANEZ; Touhami LANEZ

doi:10.24193/subbchem.2024.4.02

Authors

Chahinaz ZOUBEIDI Department of Renewable Energies, Faculty of Hydrocarbons, Renewable Energies and Earth and Universe Sciences, University of Ouargla, Ouargla, Algeria. https://orcid.org/0000-0003-2247-4920 (unauthenticated)
Ali OURARI Laboratory of Electrochemistry, Molecular Engineering and Redox Catalysis (LEIMCR), Faculty of Technology, Ferhat ABBAS University of Sétif-1, Sétif 19000, Algeria https://orcid.org/0000-0003-1978-0716 (unauthenticated)
Elhafnaoui LANEZ Department of Chemistry, VTRS Laboratory, Faculty of Sciences, University of El Oued, El Oued, Algeria https://orcid.org/0000-0002-6543-2547 (unauthenticated)
Touhami LANEZ Department of Chemistry, VTRS Laboratory, Faculty of Sciences, University of El Oued, El Oued, Algeria. Corresponding author: touhami-lanez@univ-eloued.dz https://orcid.org/0000-0002-3978-7635 (unauthenticated)

DOI:

https://doi.org/10.24193/subbchem.2024.4.02

Keywords:

Copper(II) complex, Electro-polymerization, catalytic reduction, DNA binding affinity, AutoDock

Abstract

In this study, we investigate the electrochemical properties of a novel copper complex (CuL₂) derived from the Schiff base ligand N-3-bromopropylsalicylaldimine (LH). We also examine its interaction with chicken blood double-stranded DNA (cb-ds DNA) in phosphate buffer solution (PB) at physiological pH 7.2 using cyclic voltammetry (CV) techniques. The interaction mechanism of nitrite with CuL₂, involving the CuII/CuI redox system, is explored. The CuL₂ complex was electropolymerized on glassy carbon (GC) and fluorine tin oxide (FTO). The morphology of PolyCuL₂ formed on FTO was analyzed using scanning electron microscopy (SEM) and its elemental composition determined by EDX analysis. The modified electrode polyCuL₂/GC exhibited efficient catalytic activity for the electroreduction of oxygen (O₂) in homogeneous electrocatalytic media. The binding constant (Kb) of the DNA-CuL₂ adduct, determined from CV measurements, was found to be 1.33×10⁵, closely matching the value obtained from molecular docking studies (1.75×10⁵). Docking studies indicate that the CuL₂ complex binds to DNA in the minor groove binding mode. The anodic peak potential shift in the negative direction suggests an electrostatic interaction between CuL₂ and DNA.

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Electrochemical Characterization and DNA Interaction Studies of a Novel Copper Schiff Base Complex: Insights From Cyclic Voltammetry and Molecular Docking

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