ANTIMICROBIAL ACTIVITY OF CERAMIC DISKS LOADED WITH SILVER IONS AND NITROXOLINE

Ancuta DANISTEAN; Maria GOREA; Alexandra AVRAM; Sorin RAPUNTEAN; Gheorghe TOMOAIA; Aurora MOCANU; Corina  ISTRATE (GARBO); OSSI  HOROVITZ; Maria TOMOAIA-COTISEL

ANTIMICROBIAL ACTIVITY OF CERAMIC DISKS LOADED WITH SILVER IONS AND NITROXOLINE

Authors

Ancuta DANISTEAN Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Corresponding author: maria.tomoaia@ubbcluj.ro.
Maria GOREA Department of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: mgorea@chem.ubbcluj.ro.
Alexandra AVRAM Department of Chemical Engineering, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: alexandra.avram@ubbcluj.ro. https://orcid.org/0009-0006-7583-778X
Sorin RAPUNTEAN Faculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Cluj-Napoca, Romania. Email: sorin.rapuntean@usamvcluj.ro.
Gheorghe TOMOAIA Department of Orthopedics and Traumatology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca; Academy of Romanian Scientists, Bucharest, Romania. Email: tomoaia2000@yahoo.com. https://orcid.org/0000-0002-5633-6895
Aurora MOCANU Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: aurora.mocanu@ubbcluj.ro. https://orcid.org/0000-0002-8728-045X
Corina ISTRATE (GARBO) Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Corresponding author: maria.tomoaia@ubbcluj.ro. https://orcid.org/0000-0002-7934-103X
OSSI HOROVITZ Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Corresponding author: maria.tomoaia@ubbcluj.ro. https://orcid.org/0000-0002-3652-8558
Maria TOMOAIA-COTISEL Research Center of Physical Chemistry, Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: maria.tomoaia@ubbcluj.ro. https://orcid.org/0000-0002-0995-3006

Keywords:

ceramics, hydroxyapatite, silver ions, 5-nitro-8-hydroxyquinoline, antimicrobial effect

Abstract

Ceramic porous disks made of hydroxyapatite, HAP, loaded with silver ions and nitroxoline (5-nitro-8-hydroxyquinoline, NHQ) are used in vitro against pathogens, such as Staphylococcus aureus. HAP powder was synthesized by a wet chemical method, and its phase purity and nanocrystalline structure were assessed by X-ray diffraction (XRD), transmission electron microscopy (TEM) and atomic force microscopy (AFM). Disk samples of HAP were prepared and impregnated with Ag⁺ ions and NHQ solutions. A strong antimicrobial activity of all samples was assessed by the diffusion assay in vitro against Staphylococcus aureus. Through the development of the optimal composition of these biomaterials, this approach might hold potential applications for antimicrobial coating, bone tissue engineering scaffolds and biomedical devices.

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STUDIA UBB CHEMIA, Volume 61 (LXI), No. 3, September 2016

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Published

2016-09-30

How to Cite

DANISTEAN, A., GOREA, M., AVRAM, A., RAPUNTEAN, S., TOMOAIA, G., MOCANU, A., … TOMOAIA-COTISEL, M. (2016). ANTIMICROBIAL ACTIVITY OF CERAMIC DISKS LOADED WITH SILVER IONS AND NITROXOLINE. Studia Universitatis Babeș-Bolyai Chemia, 61(3), 275–283. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8350