INCLUSION COMPOUNDS OF β-CYCLODEXTRIN-PITOFENONE HYDROCHLORIDE. INVESTIGATIONS OF SOLID FORMS

Horea Gabriel  POPENECIU; Dumitru  RISTOIU; Ioan  BRATU; Gheorghe  BORODI; Attila  BENDE; Lucian  BARBU

INCLUSION COMPOUNDS OF β-CYCLODEXTRIN-PITOFENONE HYDROCHLORIDE. INVESTIGATIONS OF SOLID FORMS

Authors

Horea Gabriel POPENECIU National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: horea.popeneciu@itim-cj.ro.
Dumitru RISTOIU Faculty of Environmental Sciences and Engineering, Babeș-Bolyai University, Cluj-Napoca, Romania. Corresponding author: borodi@itim-cj.ro.
Ioan BRATU National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: ibratu@gmail.com. https://orcid.org/0000-0002-8575-6549
Gheorghe BORODI Department of Molecular and Biomolecular Service, National Institute for Research and Development for Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: borodi@itim-cj.ro. https://orcid.org/0000-0003-4915-4169
Attila BENDE Department for Molecular and Biomolecular Physics, National Institute for Research and Development of Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: attila.bende@itim-cj.ro. https://orcid.org/0000-0002-5347-1514
Lucian BARBU Electron Microcopy Center, Faculty of Biology and Geology, Babes-Bolyai University; Integrated Electron Microscopy Laboratory, National Research and Development Institute for Isotopic and Molecular Technologies, Cluj-Napoca, Romania. Email: lucian.barbu@ubbcluj.ro. https://orcid.org/0000-0003-0360-016X

Keywords:

pitofenone hydrochloride, β-cyclodextrin, SEM, DSC, magnetic and FTIR spectroscopy, molecular modeling

Abstract

Pitofenone hydrochloride (PF.HCl) is a pharmaceutical substance used as an antispasmodic drug. The inclusion compounds of β‑cyclodexdrin (β-CD) with pitofenone hydrochloride (PF.HCl) have been prepared by co-precipitation and freeze-drying methods in order to increase the capacity user acceptance to wafer interest in terms of their taste. For physical chemical characterization, the inclusion compounds were analyzed by powder X-ray diffraction, FTIR and ss-NMR spectroscopy, DSC, SEM and the structural architecture of the inclusion compound was proposed by molecular modeling techniques. The new product obtained can be used in the pharmaceutical industry because it provides improved smell and taste as compared to the starting substance.

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STUDIA UBB CHEMIA, Volume 61 (LXI), No. 2, June 2016

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Published

2016-06-30

How to Cite

POPENECIU, H. G. ., RISTOIU, D. ., BRATU, I. ., BORODI, G. ., BENDE, A. ., & BARBU, L. . (2016). INCLUSION COMPOUNDS OF β-CYCLODEXTRIN-PITOFENONE HYDROCHLORIDE. INVESTIGATIONS OF SOLID FORMS. Studia Universitatis Babeș-Bolyai Chemia, 61(2), 61–71. Retrieved from https://studia.reviste.ubbcluj.ro/index.php/chemia/article/view/8308