ANALYSIS OF PHYTOCONSTITUENT PROFILE OF FENUGREEK –TRIGONELLA FOENUEM-GRAECUM L. - SEED EXTRACTS
DOI:
https://doi.org/10.24193/subbchem.2017.2.11Keywords:
fenugreek, Trigonella foenum-graecum, phytoconstituents, UHPLC-ESI-MSAbstract
Fenugreek (Trigonella foenum-graecum L.) is a well-known herb for its efficiency in the prevention/treatment of diabetes among other chronic diseases. The aim of present study was to analyse the phytoconstituent profile of aqueous and hydro-alcoholic extracts of fenugreek seeds produced in Hungary. The aqueous and hydro-aqueous extracts were analysed using a UHPLC-ESI-MS approach, and in the first 54, while in the second extract 67 phytoconstituents were identified that mostly corroborate the previously described health promoting effects of fenugreek. However, it remains a huge challenge to correlate the phytoconstituent composition of the two extracts with the generated dose dependent hormetic response and cytotoxic effects that were reported by us in case of some human breast cancerous cell lines.
References
Furry, Les cahiers de la recherche agronomique, 1950, 3, 25.
G.A. Petropoulus, “Agronomic, genetic and chemical studies of Trigonella foenum-graecum L.”, 1973, PhD thesis, Bath University.
M. Al-Habori, A. Raman, “Pharmacological properties”, Taylor & Francis, London UK. 2002. 162.
J.A. Duke, “Handbook of medicinal herbs”, 1986, CRC Florida, p-490.
H. Skalta, "Fenugreek: The Genus Trigonella", Taylor & Francis, London, 2002, chapter 9.
M. Yoshikawa, T. Murakami, H. Komatsu, J. Yamahara, H. Matsuda, Chemical Pharmaceutical Bulletin (Tokyo), 1997, 45 (1), 81.
M. Yoshikawa, T. Murakami, H. Komatsu, N. Murakami, J. Yamahara, H. Matsuda, Heterocycles, 1998, 47 (1), 397.
T. Murakami, A. Kishi, H. Matsuda, M. Yoshikawa, Chemical Pharmaceutical Bulletin, 1997, 48 (7), 994.
I.P. Varshney, M.F.A. Beg, Indian Journal of Chemistry, Sect.B. 1978, 16 (12), 1134.
H. Grangrade, R. Kaushal, Indian Drugs. 1979, 16 (7), 149.
P. Khanna, S.C. Jain, Lloydia, 1993, 36, 96.
R. D.Sharma, Nutrition Reports International, 1986, 33 (4), 669.
M. Shang, Y. Tezuka, S. Cai, J. Li, S. Kadota, W. Fan, T. Namba, Zhongcaoyao, 1998, 29 (10), 655.
W. Karrer, “Konstitution und Vorkommen der organischen Planzenstoffe”, Birkhäuser Verlag, Basel und Stuttgart. 1958, p.997, 1009.
J. Shani, A. Goldschmied, B. Joseph, Z. Ahronson, F.G. Sulman, Archive of International Pharmacodynamics and Therapeutics, 1974, 210 (10), 27.
M. Covello, Bollettino Della Societa Italiana Di Biologia Sperimentale, 1943, 18, 159.
M.A. Bhatti, M.T.J. Khan, B. Ahmed, M. Jamshaid, W. Ahmad, Fitoterapia, 1996, 67 (4), 372.
L. Reppel, D. Wagenbreth, Flora, 1958, 146, 212.
L. Fowden, H. Pratt, A. Smith, Phytochemistry, 1973, 12, 1707.
Y. Sauvaire, P. Girardon, J.C. Baccou, J. Ristérucci, Phytochemistry, 1984, 23 (3), 479.
H. Van Etten, R. W. Miller, I.A. Wolff, Q. Jones, Journal of Agricultural and Food Chemistry, 1961, 9 (1), 79.
M. Hidvégi, A. El-Kady, R. Lásztity, F. Békés, L. Simon-Sarkadi, Acta Alimentaria, 1984, 13, 315.
G. Valette, Y. Sauvaire, J.C. Baccou, G. Ribes, Atherosclerosis, 1984, 50 (1), 105.
G. Picci, Annali della Facoltá Agraria Universitá di Pisa, 1959, 20, 51.
K.S. Venkataramani, Indian Acaemy of Sciience, 1950, 32B, 112.
J. Hemavathy, J.V. Prabhakar, Food Chemistry, 1989, 31 (1), 1.
Sz. Vígh, Zs. Zsvér-Vadas, C. Pribac, L. Mos, Z. Cziáky, M. Czapár, C.V. Mihali, V. Turcus, E. Máthé, Studia Universitatis “Vasile Goldis”, 2016, 26 (4), 435.
G.A. Petropoulos, "Fenugreek: The Genus Trigonella", Taylor & Francis, London, 2002.
Z. Benayad, C. Gómez-Cordovés, N.E. Es-Safi, International Journal of Molecular Sciences, 2014, 15, 20668.
M. Yoshikawa, T. Murakami, H. Komatsu, N. Murakami, J. Yamahara, H. Matsuda, Chemical and Pharmaceutical Bulletin, 1997, 45, 81.
T. Murakami, A. Kishi, H. Matsuda, M. Yoshikawa, Chemical and Pharmaceutical Bulletin, 2000, 48, 994.
L. Kang, Y. Zhao, X. Pang, H. Yu, C. Xiong, J. Zhang, Y. Gao, K. Yu, C. Liu, B. Ma, Journal of Pharmaceutical and Biomedical Analysis, 2013, 74, 257.
V. Sattiraju, K. S. Chandrashekar, International Journal of Pharmacognosy and Phytochemical Research, 2014, 6, 715.
R.S. Hoffman, J.L. Kaplan, O.L. Hung, L.R. Goldfrank, Journal of Toxicology. Clinical Toxicology. 2004; 42 (4), 349.
K. Lim, F.J. Fernández-Gomez, N. Braidy, C. Estrada, C. Costa, S. Costa, A. Bessede, E. Fernandez-Villalba, A. Zinger, M.T. Herrero, G.J. Guillemin, Progress in Neurobiology, 2016, pii: S0301-0082(15)30055-1.
K. Sas, H. Robotka, J. Toldi, L. Vécsei, Journal of the Neurological Science, 2007, 257 (1-2), 221.
A. Arlt, S. Sebens, S. Krebs, C. Geismann, M. Grossmann, M.L. Kruse, S. Schreiber, H. Schäfer, Oncogene, 2013, 32 (40), 4825.
Wang, H. Sun, Y. Han, X. Wang, C. Yuan, Zhongguo Zhong Yao Za Zhi, 1997, 22 (8), 486.
M.V. Pereira Dos Santos Nascimento, F. Arruda-Silva, A.B. Gobbo Luz, B. Baratto, D. Venzke, B.G. Mendes, T.S. Fröde, M. Geraldo Pizzolatti, E.M. Dalmarco, Immunopharmacology and Immunotoxicology, 2016, 38 (5), 344.
Y.M. Tabana, L.E. Hassan, M.B. Ahamed, S.S. Dahham, M.A. Iqbal, M.A. Saeed, M.S. Khan, D. Sandai, A.S. Majid, C.E. Oon, A.M. Majid, Microvascular Research, 2016, 107, 17.
A. Nishina, M. Ukiya, M. Fukatsu, M. Koketsu, M. Ninomiya, D. Sato, J. Yamamoto, K. Kobayashi-Hattori, T. Okubo, H. Tokuoka, H. Kimura, Biologycal and Pharmaceutical Bullettin, 2015, 38 (11), 1794.
Y. Yang, X. Zhou, M. Xiao, Z. Hong, Q. Gong, L. Jiang, J. Zhou, Journal of Huazhong University of Science and Technology. Medical Sciences, 2010, 30 (6), 734.
Arbabi, G. Hamidi, S.A. Talaei, M. Salami, Iranian Journal of Basic Medical Sciences, 2016, 19 (12), 1285.
Shafiee, M. Saidijam, H. Tavilani, N. Ghasemkhani, I. Khodadadi, International Journal of Molecular and Cellular Medicine, 2016, 5 (3), 178.
M. He, J.W. Min, W.L. Kong, X.H. He, J.X. Li, B.W. Peng, Fitoterapia, 2016, 115, 74.
M. Dixit, A. Raghuvanshi, C.P. Gupta, J. Kureel, M.N. Mansoori, P. Shukla, A.A. John, K. Singh, D. Purohit, P. Awasthi, D. Singh, A. Goel, PLoS One, 2015, 10 (12), e0144541.
Gatouillat, A.A. Magid, E. Bertin, H. El btaouri, H. Morjani, C. Lavaud, C. Madoulet, Phytomedicine, 2015, 22 (13), 1186.
C. Nguyen, J.F. Savouret, M. Widerak, M.T. Corvol, F. Rannou, Nutrients. 2017, 9 (1), pii: E45.
F. Peraza-Luna, M. Rodríguez-Mendiola, C. Arias-Castro, J. M. Bessiere, G. Calva-Calva, Journal of Agricultural and Food Chemistry, 2001, 49 (12), 6012.
C. Scholtes, S. Nizet, S. Collin, Journal of Agricultural and Food Chemistry, 2015, 63 (11), 2886.
P. Haberstich, C.H. Kindler, M. Schürch, Anaesthesist, 2010, 59 (10), 914.
A. Taylor, L.C. Schenkel, M. Yokich, M. Bakovic, Biochemistry and Cell Biology, 2016, 6, 1.
E. Kiyota, I.A. Pena, P. Arruda, Plant, Cell and Environment, 2015, 38 (11), 2450.
T. Sato, Y. Ito, T. Nagasawa, Molecular and Cellular Biochemistry. 2015, 410 (1-2), 93.
D.O. Adams, S.F. Yang, Plant Physiology, 1977, 60 (6), 892.
Y. Xiao, X. Su, W. Huang, J. Zhang, C. Peng, H. Huang, X. Wu, H. Huang, M. Xia, W. Ling, The International Journal of Biochemistry and Cell Biology, 2015, 67, 158.
Z. Tavassoli, M. Taghdir, B. Ranjbar, Journal of Biomolecular and Structure Dynamics, 2017, 19, 1.
S. Mocellin, M. Briarava, P. Pilati Journal of the National Cancer Institute, 2016, 109 (3), pii: djw230.
S.C. Gominak, Medical Hypotheses, 2016, 94, 103.
Ding, H. Wang, L. Zhu, W. Wei, Neurochemical Research, 2016, doi: 10.1007/s11064-016-2077-8.
W.T. Gai, D.P. Yu, X.S. Wang, P.T. Wang, Oncology Letters, 2016, 12 (4), 2880.
L. Gao, Y.M. Shui, W. Jiang, E.Y. Huang, Q.Y. Shou, X. Ji, B.C. He, G.Y. Lv, T.C. He, Oncotarget, 2016, doi: 10.18632/oncotarget.12375.
D. Koupý, H. Kotolová, J. Rudá Kučerová, Ceska a Slovenska Farmacie, 2015, 64 (3), 67.
E.J. Calabrese, L. A. Baldwin, Human and Experimental Toxicology, 2002, 21, 91.
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