AN ECOLOGICAL TREATMENT METHOD FOR IFOSFAMIDE CONTAMINATED WASTE WATER RESULTING FROM ONCOLOGICAL THERAPY

Authors

  • Valentin ORDODI Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania; SC Natural Ingredients R&D SRL, Tabacari Street, No. 10/1, RO-505200, Făgăraș, Romania
  • Ana-Maria PANĂ Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania https://orcid.org/0000-0001-5424-7883
  • Alina DUMITREL Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania. *Corresponding author: alina.dumitrel@upt.ro https://orcid.org/0000-0002-2097-5230
  • Daniel HĂDĂRUGĂ Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania https://orcid.org/0000-0002-6326-413X
  • Andra TĂMAȘ Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania
  • Vasile PODE Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania
  • Anamaria TODEA Politehnica University of Timișoara, 2 Victoriei Square, RO-300006, Timișoara, Romania https://orcid.org/0000-0001-7744-103X
  • Virgil PĂUNESCU niversity of Medicine and Pharmacy “V. Babeș” Timișoara, 2 Eftimie Murgu Square RO-300041, Timișoara, Romania
  • Șerban NEGRU niversity of Medicine and Pharmacy “V. Babeș” Timișoara, 2 Eftimie Murgu Square RO-300041, Timișoara, Romania

DOI:

https://doi.org/10.24193/subbchem.2020.1.21

Keywords:

electrochemical wastewater treatment, ifosfamide, electrooxidation, asymmetric current density reactor

Abstract

Ifosfamide is a potent alkylating agent used to treat many forms of human cancer. Exposure to this substance for the long term even in small quantities has serious negative effects on human health and the environment. This study presents an ecological method of electrochemical inactivation of ifosfamide in an automatic laboratory installation. The neutralization process consists of ifosfamide electrochemical and chemical oxidation via reactive chlorine species generated in situ at the anode of the electrochemical reactor with asymmetric current densities. The neutralization efficiency of ifosfamide using this method is approximately 99% if the duration of the electrodegradation process under the presented conditions is 30 minutes.

References

S. Hellweg, B. Thomas, H. K. Hungerbühler, “Modeling waste incineration for life-cycle inventory analysis in Switzerland. Environmental Modeling and Assesment”, Kluwer Academic Publishers, 2001.

E. A. Cociş, V. F. Soporan, P. Ilea, F. Imre-Lucaci, B. M. Soporan, P. Bere, O. Nemeş, Studia UBB Chemia, 2012, LVII, 2, 147.

International Agency for Research on Cancer, “IARC Monograph on the Evaluation of Carcinogenic Risks to Humans: List of IARC Evaluations” IARC Lyon, France, 1996.

M.Ikematsu, K. Kaneda, M. Iseki, M. Yasuda, Sci. Total Environm., 2007, 382, 159-164.

F.l Badulescu, V. Voicu, L. Pop, A. Badulescu, “Vademecum de chimioterapie antineoplazica”, Editura Medicala, Bucuresti, 1999.

N. Ghilezan, “Oncologie Generala”, Editura Medicala, Bucuresti, 1982.

M.C. Mirica, “Reactoare electrochimice cu densități de curent asimetrice”, Teză de doctorat, Craiova, 2005.

K. Yoshida, “Electrooxidation in Organic Chemistry”, Krieger Publishing Company, Malabar Florida 1993.

S. Fogarasi, F. Imre-Lucaci, A. Ghirişan, B. R. H. Mişca, A. Imre-Lucaci, Studia UBB Chemia, 2016, LXI(3), 145.

D. J. Pickett, “Electrochemical reactor design”, Elsevier, Amsterdam, 1979.

A. Nichici, E. Cicală, R. Mee, “Prelucrarea datelor experimentale. Curs şi aplicaţii”, Centrul de multiplicare, Timişoara, 1996.

G.A. Brusturean, T. Todinca, D. Perju, J. Carre, Environm. Technol, 2007, 28(10), 1153-1162.

V. Ordodi, G.A. Dumitrel, A. Gruia, M. Iacob, A. F. Mic, G. Jinescu, D. Perju, Revista de Chimie (Bucharest), 2010, 61(9), 857-861.

J. Hirose, F. Kondo, T. Nakano, T. Kobayashi, N. Hiro, Y. Ando, H. Takenaka, K. Sano, Chemosphere, 2005, 60, 1018-1024.

M. Ikematsu, K. Kaneda, M. Iseki, M. Yasuda, Sci. Total Environm., 2007, 382, 159-164.

S. Hansel, M. Castegnaro, M. H. Sportouch, M. De Meo, J. C. Milhavet, M. Laget, G. Dumenil, Int. Arch. Occup. Environm. Health, 1997, 69, 109-114.

A. Oprisoni, S. Arghirescu, C. Jinca, L. Balint-Gib, A. Isac, V. Ordodi, M. Baica, G. Doros, M. Serban. Abstracts of the 36th Annual Meeting of the European Group for Blood and Bone Marrow Transplantation, Bone Marrow Transplantation, 2010, 45, S78-S327.

B. B. Park, W. S. Kim, H. S. Eom, J. S. Kim, Y. Y. Lee, S. J. Oh, D. H. Lee, C. Suh, Invest New Drugs, 2011, 29, 154-160.

R. R. Larson, M. B. Khazaeli, H. K. Dillon, Applied Occupational and Environmental Hygiene, 2003, 18(2), 109-119.

J.J. Kirkland, L.R.Synder, “Introduction to Modern Liquid Chromatography”, 2nd Edition, Jon Wiley and Sons, New York, 1979.

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Published

2020-03-20

How to Cite

ORDODI, V., PANĂ, A.-M. ., DUMITREL, A., HĂDĂRUGĂ, D., TĂMAȘ, A., PODE, V., … NEGRU, Șerban. (2020). AN ECOLOGICAL TREATMENT METHOD FOR IFOSFAMIDE CONTAMINATED WASTE WATER RESULTING FROM ONCOLOGICAL THERAPY. Studia Universitatis Babeș-Bolyai Chemia, 65(1), 267–277. https://doi.org/10.24193/subbchem.2020.1.21

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