AN ECOLOGICAL TREATMENT METHOD FOR IFOSFAMIDE CONTAMINATED WASTE WATER RESULTING FROM ONCOLOGICAL THERAPY
DOI:
https://doi.org/10.24193/subbchem.2020.1.21Keywords:
electrochemical wastewater treatment, ifosfamide, electrooxidation, asymmetric current density reactorAbstract
Ifosfamide is a potent alkylating agent used to treat many forms of human cancer. Exposure to this substance for the long term even in small quantities has serious negative effects on human health and the environment. This study presents an ecological method of electrochemical inactivation of ifosfamide in an automatic laboratory installation. The neutralization process consists of ifosfamide electrochemical and chemical oxidation via reactive chlorine species generated in situ at the anode of the electrochemical reactor with asymmetric current densities. The neutralization efficiency of ifosfamide using this method is approximately 99% if the duration of the electrodegradation process under the presented conditions is 30 minutes.References
S. Hellweg, B. Thomas, H. K. Hungerbühler, “Modeling waste incineration for life-cycle inventory analysis in Switzerland. Environmental Modeling and Assesment”, Kluwer Academic Publishers, 2001.
E. A. Cociş, V. F. Soporan, P. Ilea, F. Imre-Lucaci, B. M. Soporan, P. Bere, O. Nemeş, Studia UBB Chemia, 2012, LVII, 2, 147.
International Agency for Research on Cancer, “IARC Monograph on the Evaluation of Carcinogenic Risks to Humans: List of IARC Evaluations” IARC Lyon, France, 1996.
M.Ikematsu, K. Kaneda, M. Iseki, M. Yasuda, Sci. Total Environm., 2007, 382, 159-164.
F.l Badulescu, V. Voicu, L. Pop, A. Badulescu, “Vademecum de chimioterapie antineoplazica”, Editura Medicala, Bucuresti, 1999.
N. Ghilezan, “Oncologie Generala”, Editura Medicala, Bucuresti, 1982.
M.C. Mirica, “Reactoare electrochimice cu densități de curent asimetrice”, Teză de doctorat, Craiova, 2005.
K. Yoshida, “Electrooxidation in Organic Chemistry”, Krieger Publishing Company, Malabar Florida 1993.
S. Fogarasi, F. Imre-Lucaci, A. Ghirişan, B. R. H. Mişca, A. Imre-Lucaci, Studia UBB Chemia, 2016, LXI(3), 145.
D. J. Pickett, “Electrochemical reactor design”, Elsevier, Amsterdam, 1979.
A. Nichici, E. Cicală, R. Mee, “Prelucrarea datelor experimentale. Curs şi aplicaţii”, Centrul de multiplicare, Timişoara, 1996.
G.A. Brusturean, T. Todinca, D. Perju, J. Carre, Environm. Technol, 2007, 28(10), 1153-1162.
V. Ordodi, G.A. Dumitrel, A. Gruia, M. Iacob, A. F. Mic, G. Jinescu, D. Perju, Revista de Chimie (Bucharest), 2010, 61(9), 857-861.
J. Hirose, F. Kondo, T. Nakano, T. Kobayashi, N. Hiro, Y. Ando, H. Takenaka, K. Sano, Chemosphere, 2005, 60, 1018-1024.
M. Ikematsu, K. Kaneda, M. Iseki, M. Yasuda, Sci. Total Environm., 2007, 382, 159-164.
S. Hansel, M. Castegnaro, M. H. Sportouch, M. De Meo, J. C. Milhavet, M. Laget, G. Dumenil, Int. Arch. Occup. Environm. Health, 1997, 69, 109-114.
A. Oprisoni, S. Arghirescu, C. Jinca, L. Balint-Gib, A. Isac, V. Ordodi, M. Baica, G. Doros, M. Serban. Abstracts of the 36th Annual Meeting of the European Group for Blood and Bone Marrow Transplantation, Bone Marrow Transplantation, 2010, 45, S78-S327.
B. B. Park, W. S. Kim, H. S. Eom, J. S. Kim, Y. Y. Lee, S. J. Oh, D. H. Lee, C. Suh, Invest New Drugs, 2011, 29, 154-160.
R. R. Larson, M. B. Khazaeli, H. K. Dillon, Applied Occupational and Environmental Hygiene, 2003, 18(2), 109-119.
J.J. Kirkland, L.R.Synder, “Introduction to Modern Liquid Chromatography”, 2nd Edition, Jon Wiley and Sons, New York, 1979.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2020 Studia Universitatis Babeș-Bolyai Chemia
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.