CANNABIDIOL CONTENT EVALUATION IN COMMERCIAL DIETARY SUPPLEMENTS AND STABILITY IN OIL VEHICLE

Robert-Alexandru VLAD; Lénárd FARCZÁDI; Camelia-Maria TOMA; Silvia IMRE; Paula ANTONOAEA; Emőke Margit RÉDAI; Daniela-Lucia MUNTEAN; Adriana CIURBA

doi:10.24193/subbchem.2021.2.26

CANNABIDIOL CONTENT EVALUATION IN COMMERCIAL DIETARY SUPPLEMENTS AND STABILITY IN OIL VEHICLE

Authors

Robert-Alexandru VLAD eorge Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and Cosmetology Department, Targu Mures, Romania.
Lénárd FARCZÁDI George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Center for Advanced Medical and Pharmaceutical Research, Targu Mures, Romania. *Corresponding author: lenard.farczadi@umfst.ro
Camelia-Maria TOMA George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Center for Advanced Medical and Pharmaceutical Research, Targu Mures, Romania.
Silvia IMRE George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Pharmacy, Analytical Chemistry and Drug Analysis Department, Targu Mures, Romania. https://orcid.org/0000-0002-4625-6525
Paula ANTONOAEA George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and Cosmetology Department, Targu Mures, Romania.
Emőke Margit RÉDAI George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and Cosmetology Department, Targu Mures, Romania
Daniela-Lucia MUNTEAN George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Pharmacy, Analytical Chemistry and Drug Analysis Department, Targu Mures, Romania.
Adriana CIURBA George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mures, Faculty of Pharmacy, Pharmaceutical Technology and Cosmetology Department, Targu Mures, Romania.

DOI:

https://doi.org/10.24193/subbchem.2021.2.26

Keywords:

CBD-oil, dietary supplements, storage, CBD powders, decomposition.

Abstract

Cannabidiol (CBD) is one of the most studied alkaloids found in Cannabis species. Also, its occurrence in Cannabis plants is higher in most of cases compared with the addictive compound named tetrahydrocannabinol (THC). This study aimed to evaluate CBD concentrations and stability in different commercial products and reconstituted oil. An UHPLC method previously published was applied. Three CBD oils and two powders marketed online together with a reconstituted oil were analyzed. The oils presented concentrations lower than stated on the label. The content of reconstituted CBD oils prepared similarly to the commercial oils decrease linearly with small differences based on the storage conditions. Thus, the CBD oil kept at temperatures of 5±0.3°C tends to decompose slightly slower compared with the oil kept at room temperature. A stabilizer may be needed to slow the decomposition process. Future studies for reconstituted formulation may be needed to establish if the type of oil used is influencing the decomposition process.

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STUDIA UBB CHEMIA, Volume 66 (LXVI), No. 2, June 2021

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Published

2021-06-30

How to Cite

VLAD, R.-A., FARCZÁDI, L., TOMA, C.-M., IMRE, S., ANTONOAEA, P., RÉDAI, E. M., … CIURBA, A. (2021). CANNABIDIOL CONTENT EVALUATION IN COMMERCIAL DIETARY SUPPLEMENTS AND STABILITY IN OIL VEHICLE. Studia Universitatis Babeș-Bolyai Chemia, 66(2), 299–308. https://doi.org/10.24193/subbchem.2021.2.26