ECO-FRIENDLY ENZYMATIC SYNTHESIS OF ANISYL PROPIONATE MEDIATED BY LIPASE B FROM CANDIDA ANTARCTICA

Authors

  • Diana Maria SCROB Enzymology and Applied Biocatalysis Research Center, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Arany János str. 11, RO-400028, Cluj-Napoca, Romania.
  • Mihai Andrei LĂCĂTUȘ Enzymology and Applied Biocatalysis Research Center, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Arany János str. 11, RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0002-4625-6525
  • Adrian Ioan DUDU Enzymology and Applied Biocatalysis Research Center, Faculty of Chemistry and Chemical Engineering, Babeș-Bolyai University, Arany János str. 11, RO-400028, Cluj-Napoca, Romania. *Corresponding author: adrian.dudu@ubbcluj.ro https://orcid.org/0000-0002-4625-6525

DOI:

https://doi.org/10.24193/subbchem.2021.2.24

Keywords:

lipase, aroma, flavor, biocatalysis, esterification, green solvent.

Abstract

In this paper we report a biocatalytic approach for the efficient synthesis of anisyl propionate by direct esterification of anisyl alcohol with propionic acid mediated by commercially available Novozym 435, in presence of molecular sieves which serves for the efficient removal of water formed in the reaction. Process optimization was performed regarding the optimal solvent (2-methyltetrahydrofuran), temperature (60°C), and molecular sieves load (100 mg/mL). Further scaling-ups were performed under optimal conditions increasing the substrates concentration up to 1000 mM with unaltered conversions in anisyl propionate (>95 % after 6 hours reaction time).

References

M.A. Longo; M.A. Sanroman; Food Technol. Biotechnol.; 2006; 44; 335-353

A.G. Almeida Sa; A.C. de Meneses; L.A. Lerin; P.H.H. de Araujo; C. Sayer; D. de Oliveira; Bioproc. Biosyst. Eng.; 2018; 41; 585-591

A.I. Dudu; M.A. Lăcătuș; L.C. Bencze; C. Paizs; M.I. Toșa; ACS Sustain. Chem. Eng.; 2021; 9; 5461-5469

M. Sarno; M. Iuliano; M. Polichetti; P. Ciambelli; Process Biochem.; 2017; 56; 98-108

C. Vasilescu; A. Todea; A. Nan; M. Circu; R. Turcu; I.C. Benea; F. Peter; Food Chem.; 2019; 296; 1-8

A.C. de Meneses; A.G. Almeida Sa; L.A. Lerin; M.L. Corazza; P.H.H. de Araujo; C. Sayer; D. de Oliveira; Process Biochem.; 2019; 78; 50-57

Z. Gao; J. Chu; T. Jiang; T. Xu; B. Wu; B. He; Process Biochem.; 2018; 64; 152-159

S. Asmat; A.H. Anwer; Q. Husain; Int. J. Biol. Macromol.; 2019; 140; 484-495

O. Barbosa; C. Ortiz; R. Torres; R.F. Lafuente; J. Mol. Catal. B Enzym.; 2011; 71; 124-132

J.L.R. Friedrich; F.P. Pena; C. Garcia-Galan; R. Fernandez-Lafuente; M.A.Z. Ayub; R.C. Rodrigues; J. Chem. Technol. Biotechnol; 2012; 88; 1089-1095

M.C.M. de Souza; K.P. dos Santos; R.M. Freire; A.C.H. Barreto; P.B.A. Fechine; L.R.B. Goncalves; Braz. J. Chem. Eng.; 2017; 34; 681-690

H.V. Ferreira; L.C. Rocha; R.P. Severino; A.L.M. Porto; Molecules; 2012; 17; 8955-8967

R.N. Patel; A. Banerjee; V. Nanduri; A. Goswami; F.T. Comezoglu; J. Am. Oil Chem. Soc.; 2000; 77; 1015-1019

V. Pace; P. Hoyos; L. Castoldi; P.D. de Maria; A.R. Alcantara; ChemSusChem; 2012; 5; 1369-1379

M.A. Lacatus; L.C. Bencze; M.I. Toșa; C. Paizs; F.D. Irimie; ACS Sustain. Chem. Eng.; 2018; 6; 11353-11359

STUDIA UBB CHEMIA, Volume 66 (LXVI), No. 2, June 2021

Downloads

Published

2021-06-30

How to Cite

SCROB, D. M., LĂCĂTUȘ, M. A., & DUDU, A. I. (2021). ECO-FRIENDLY ENZYMATIC SYNTHESIS OF ANISYL PROPIONATE MEDIATED BY LIPASE B FROM CANDIDA ANTARCTICA. Studia Universitatis Babeș-Bolyai Chemia, 66(2), 277–286. https://doi.org/10.24193/subbchem.2021.2.24

Issue

Volume 66, No. 2, 2021

Section

Articles

License

Copyright (c) 2021 Studia Universitatis Babeș-Bolyai Chemia

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.