THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL PHOTOSENSITIZERS IN INDUCED PERIODONTITIS

Ariadna  PĂUN; Laura Monica  RUSU; Mărioara  MOLDOVAN; Sorina  SAVA; Alexandra  DREANCĂ; Cecilia  BACALI; Mîndra Eugenia  BADEA; Cristina  BORZAN; Ioana  BÂLDEA

doi:10.24193/subbchem.2023.2.06

THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL PHOTOSENSITIZERS IN INDUCED PERIODONTITIS

Authors

Ariadna PĂUN Department of Public Health and Management, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Corresponding author: dascalu.monica@umfcluj.ro.
Laura Monica RUSU Assistant Lecturer PhD, Department of Prosthodontics and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: dascalu.monica@umfcluj.ro. https://orcid.org/0000-0001-5191-6738
Mărioara MOLDOVAN Department of Polymer Composites, Raluca Ripan Institute for Researh in Chemistry, Babeş-Bolyai University, Cluj-Napoca, Romania. Email: iccrr@ubbcluj.ro. https://orcid.org/0000-0001-9714-4809
Sorina SAVA Department of Prosthodontics and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: savasorina@yahoo.com. https://orcid.org/0000-0001-8658-1384
Alexandra DREANCĂ Department of Pathophysiology/Toxicology, University of Agricultural Science and Veterinary Medicine, Cluj-Napoca, Romania. Email: alexandra.dreanca@usamvcluj.ro. https://orcid.org/0000-0002-8421-8546
Cecilia BACALI Department of Prosthodontics and Dental Materials, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: cecilia.bacali@umfcluj.ro. https://orcid.org/0000-0001-5706-322X
Mîndra Eugenia BADEA Department of Preventive Dental Medicine, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: mebadea@umfcluj.ro. https://orcid.org/0000-0003-3136-6956
Cristina BORZAN Department of Public Health and Management, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: borzancristina@yahoo.com. https://orcid.org/0000-0003-1558-3782
Ioana BÂLDEA Department of Physiology, Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania. Email: ioana.baldea@umfcluj.ro. https://orcid.org/0000-0003-4046-7310

DOI:

https://doi.org/10.24193/subbchem.2023.2.06

Keywords:

Oxidative stress, essential oils, photodynamic therapy

Abstract

The aim of this study is to identify and test new natural photosensitizers used in antibacterial photodynamic therapy due to the antimicrobial and antioxidant effect they present. The experimental study was conducted on rats in which periodontal disease was induced. As treatment, photodynamic therapy was used in the presence of new developed natural photosensitizers based on oregano essential oil and curcumin extract. Malondialdehyde as well as low and oxidized glutathione levels were measured by spectrophotometry to assess oxidative stress in treated groups of rats. New photosensitizers were characterized by modern testing methods, using FTIR infrared spectroscopy, gas chromatography-mass spectrometry and UV-Vis analysis. The results obtained suggest that the prooxidant effect is mainly due to exposure to photodynamic therapy (irradiation) and leads to the antibacterial therapeutic effect that is maintained even when applying gels with antioxidant agents.

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STUDIA UBB CHEMIA, Volume 68 (LXVIII), No. 2, June 2023

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Published

2023-06-30

How to Cite

PĂUN, A. ., RUSU, L. M. ., MOLDOVAN, M. ., SAVA, S. ., DREANCĂ, A. ., BACALI, C. ., … BÂLDEA, I. . (2023). THE ANTIOXIDANT EFFECT AND CHEMICAL COMPOSITION OF TWO EXPERIMENTAL PHOTOSENSITIZERS IN INDUCED PERIODONTITIS. Studia Universitatis Babeș-Bolyai Chemia, 68(2), 85–97. https://doi.org/10.24193/subbchem.2023.2.06