A COMPARISON BETWEEN INSULIN RESISTANCE SCORES PARAMETERS IN IDENTIFYING PATIENTS WITH METABOLIC SYNDROME
DOI:
https://doi.org/10.24193/subbchem.2019.1.12Keywords:
insulin, glycemia, HOMA, QUICKI, McAuley, metabolic syndromeAbstract
As a consequence of the epidemic of obesity, prediction of metabolic syndrome (MetS) is relevant because of its subsequent association with type 2 diabetes and cardiovascular disease. Also, MetS is considered a state of insulin resistance (IR). This study aimed to evaluate the capacity of different indirect IR scores to identify patients with MetS, compared to standard criteria of MetS diagnosis. To the best of our knowledge, the cut-off values of these indexes, as indicators of MetS, in the Romanian population, have not been established. We used a non-parametric extension of the induced ROC regression methodology to determine the cut-off values of HOMA-IR, QUICKI, McAuley indexes, taking into account the MetS components instead of using 90th percentile criteria. Although HOMA is more commonly used in practice (probably due to its easy use), McAuley Score seems to have a better specificity in identifying patients with MetS. This is different between men and women; if in women, McAuley index has the highest sensitivity, in men, HOMA and QUICKI indexes have the highest sensitivity and specificity.
References
Bertoni A.G., Wong N.D., Shea S., Ma S., Liu K, Preethi S., Jacobs D.R., Wu C., Saad M.F., Szkio M., Diabetes Care, 2007, 30, 2951–2956.
Montecucco F., Steffens S., Mach F., Mediators of Inflammation, 2008, 767623.
Tenenbaum A., Adler Y., Boyko V., American Heart Journal, 2007; 153, 559.
Verhagen S.N., Wassink A.M., van der Graaf Y., Gorter P.M., Visseren F.L., Cardiovascular Diabetology, 2011; 10, 100.
Zuliani G., Morieri M.L., Volpato S, Atherosclerosis, 2014; 235, 538.
Nasr G., Sliem H., The International Journal of Cardiovascular Imaging 2011; 27, 335.
Gazzaruso C., Solerte S.B., De Amici E., The American Journal of Cardiology, 2006; 97: 236–239.
Tataru D.A., Olinic D.M., Urda A., Olinic M., Orasan R., Studia UBB Chemia, 2018, 62, 127.
Alberti, K.G., P. Zimmet and J. Shaw, Diabetic Medicine, 2006, 23(5) 469.
Matthews, D.R., J.P. Hosker, A.S. Rudenski, B.A. Naylor, D.F. Treacher and R.C. Turner, Diabetologia, 1985, 28(7) 412.
Katz, A., S.S. Nambi, K. Mather, A.D. Baron, D.A. Follmann, G. Sullivan and M. J. Quon, The Journal of Clinical Endocrinology and Metabolism, 2000, 85(7) 2402.
McAuley K.A., Williams S.M., Mann J.I., Walker R.J., Lewis-Barned N.J., Temple L.A., Duncan A.W., Diabetes Care, 2001, 24(3), 460.
Abbasi, F., D. Shiffman, C.H. Tong, J.J. Devlin and M.J. McPhaul, Journal of the Endocrine Society, 2018, 2(9),1050.
Gayoso-Diz, P., A. Otero-Gonzalez, M.X. Rodriguez-Alvarez, F. Gude, F. Garcia, A. De Francisco and A.G. Quintel, BMC Endocrine Disorders, 2013, 13, 47.
Carvalho C., Nutrition, 2018, https,//doi.org/10.1016/j.nut.2018.07.014.
Geloneze B., Vasques A.C., Stabe C.F., Pareja J.C., Rosado L.E., Queiroz E.C., Arquivos Brasileiros de Endocrinologia & Metabologia, 2009, 53, 281-7.
Esteghamati A., Ashraf H., Khalilzadeh O., Zandieh A., Nakhjavani M., Rashidi A., Haghazali M., Asgari F., Nutrition & Metabolism, 2010, 7, 26.
Antuna-Puente B., Disse E., Rabasa-Lhoret R., Laville M., Capeau J., Bastard, Diabetes & Metabolism, 2011, 37, 179.
Saplontai-Pop A., Moldovan M., Oprean R. Orasan. O., Saplontai S., Ionescu C., Studia UBB Chemia, 2014, 59(4), 39.
Gayoso-Diz P., Otero-González A., Rodriguez-Alvarez M.X., Gude F., Cadarso-Suarez C., García F., De Francisco A, Diabetes Research and Clinical Practice, 2011, 94, 146.
Miccoli R., Biamchi C., Odoguardi, Nutrition, Metabolism and Cardiovascular Diseases, NMCD, 2005, 15, 250.
Ascaso J.F., Romero P., Real J.T., Priego A., Valdecabres C., Carmena R. Medicina Clinica (Barc), 2001, 117, 530.
Shalaurova I., Connelly M.A., Garvey T.W., and Otvos D.J., Metabolic syndrome and related disorders, 2014, (12) 8, 422.
Tosi F., Bonora E., Paolo Moghetti P, Human Reproduction, 2017, 32(12), 2515.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Studia Universitatis Babeș-Bolyai Chemia
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
