SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW PYRROLO[3’,4’:3,4]PYRROLO[1,2-a]QUINOLINE AND PYRROLO[3',4':3,4]PYRROLO[2,1-a]ISOQUINOLINE DERIVATIVES

Cristina M. AL  MATARNEH; Monica C.  SARDARU; Mircea O.  APOSTU; Irina  ROSCA; Catalina I.  CIOBANU; Ionel I.  MANGALAGIU; Ramona  DANAC

doi:10.24193/subbchem.2019.3.06

Authors

Cristina M. AL MATARNEH Department of Chemistry, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Corresponding author: rdanac@uaic.ro. https://orcid.org/0000-0001-9299-1347
Monica C. SARDARU Department of Chemistry, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Corresponding author: rdanac@uaic.ro. https://orcid.org/0000-0002-0010-3574
Mircea O. APOSTU Department of Chemistry, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Corresponding author: rdanac@uaic.ro. https://orcid.org/0000-0002-7050-5472
Irina ROSCA Department of Chemistry, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Corresponding author: rdanac@uaic.ro. https://orcid.org/0000-0003-3080-1709
Catalina I. CIOBANU Research Department, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Corresponding author: rdanac@uaic.ro. https://orcid.org/0000-0002-4264-9049
Ionel I. MANGALAGIU Research Department, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Corresponding author: ionelm@uaic.ro. https://orcid.org/0000-0002-4632-5076
Ramona DANAC Research Department, Faculty of Chemistry, “Al. I. Cuza” University, Iasi, Romania. Email: rdanac@uaic.ro. https://orcid.org/0000-0003-4370-5353

DOI:

https://doi.org/10.24193/subbchem.2019.3.06

Keywords:

heterocycles, cycloaddition, quinolines, isoquinolines, antibacterial

Abstract

Two series of new fused pyrrolo[3’,4’:3,4]pyrrolo[1,2-a]quinoline and pyrrolo[3',4':3,4]pyrrolo[2,1-a]isoquinoline derivatives were synthesized and evaluated for the antimicrobial activity. The synthetic approach involves cycloimmonium ylides as 1,3-dipol intermediates. The structures of all synthesized compounds were proved by analytical and spectroscopic data. Crystal structure of compound 11a has been also determined by single crystal XRD. The synthesized compounds were evaluated for their expected antimicrobial activity against Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922 and Candida albicans ATCC10231, but no one showed activity against all the reference strains.

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SYNTHESIS AND ANTIBACTERIAL EVALUATION OF NEW PYRROLO[3’,4’:3,4]PYRROLO[1,2-a]QUINOLINE AND PYRROLO[3',4':3,4]PYRROLO[2,1-a]ISOQUINOLINE DERIVATIVES

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