INVESTIGATION OF SYNERGIC/ANTI-SYNERGIC INTERACTIONS OF DIHYDROXIFUMARIC ACID AND ASCORBIC ACID WITH DPPH

Crina VICOL; Claudia CIMPOIU; Gheorghe DUCA

doi:10.24193/subbchem.2021.2.04

INVESTIGATION OF SYNERGIC/ANTI-SYNERGIC INTERACTIONS OF DIHYDROXIFUMARIC ACID AND ASCORBIC ACID WITH DPPH

Authors

Crina VICOL Institute of Chemistry, 3 Academiei, MD-2028, Chisinau, Republic of Moldova. *Corresponding author: crina.smigon@gmail.com https://orcid.org/0000-0002-3466-0803
Claudia CIMPOIU Babeş-Bolyai University, Faculty of Chemistry and Chemical Engineering, 11 Arany Janos, RO-400028, Cluj-Napoca, Romania. https://orcid.org/0000-0001-5960-9118
Gheorghe DUCA Institute of Chemistry, 3 Academiei, MD-2028, Chisinau, Republic of Moldova. https://orcid.org/0000-0001-7265-6293

DOI:

https://doi.org/10.24193/subbchem.2021.2.04

Keywords:

dihydroxyfumaric acid, ascorbic acid, DPPH, wine matrix, stopped-flow.

Abstract

Reaction of the free-radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) with dihydroxyfumaric acid (DHF) and ascorbic acid (AA) was investigated in ethanolic media and in wine simulated matrix by using a stopped-flow system. The antioxidant activity for both acids were significantly higher in wine matrix, the observed constants (k_obs) being about 3 s^-1 for DHF and 0.66 s^-1 for AA. Synergic and anti-synergic interactions of DHF and AA against DPPH were also investigated. A strong anti-synergic effect was noticed in ethanol (k_{obs <}0.35 s^-1). In wine simulated matrix the constants were higher than in ethanol (k_obs≈ 1 s^-1), but still too small for a synergic effect. Some explanations concerning the mechanisms of antioxidant action are proposed.

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STUDIA UBB CHEMIA, Volume 66 (LXVI), No. 2, June 2021

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Published

2021-06-30

How to Cite

VICOL, C., CIMPOIU, C., & DUCA, G. (2021). INVESTIGATION OF SYNERGIC/ANTI-SYNERGIC INTERACTIONS OF DIHYDROXIFUMARIC ACID AND ASCORBIC ACID WITH DPPH. Studia Universitatis Babeș-Bolyai Chemia, 66(2), 49–58. https://doi.org/10.24193/subbchem.2021.2.04