PRACTICAL INVESTIGATION OF GELS CONTAINING ARISTOLOCHIA (ARISTOLOCHIA CLEMATITIS) EXTRACT

Paul  ATYIM; Neli-Kinga  OLAH; Gyöngyi  OSSER; Claudia-Crina TOMA; Claudiu  MORGOVAN; Elisabeta  ATYIM

doi:10.24193/subbchem.2017.1.13

PRACTICAL INVESTIGATION OF GELS CONTAINING ARISTOLOCHIA (ARISTOLOCHIA CLEMATITIS) EXTRACT

Authors

Paul ATYIM Department of Pharmaceutical Sciences, Faculty of Pharmacy, Vasile Goldis Western University, Arad, Romania. Email: dpatyim@yahoo.co.uk.
Neli-Kinga OLAH Faculty of Pharmacy, Vasile Goldiș Western University, Arad; SC PlantExtrakt SRL, Rădaia, Cluj, Romania. Corresponding author: dpatyim@yahoo.co.uk. https://orcid.org/0000-0001-5204-6885
Gyöngyi OSSER Department of Pharmaceutical Sciences, Faculty of Pharmacy, Vasile Goldis Western University, Arad, Romania. Corresponding author: dpatyim@yahoo.co.uk. https://orcid.org/0009-0007-8181-4581
Claudia-Crina TOMA Faculty of Pharmacy, Vasile Goldiș Western University, Arad, Romania. Email: claudiatoma2004@yahoo.com. https://orcid.org/0000-0003-1515-3256
Claudiu MORGOVAN Department of Pharmaceutical Sciences, Faculty of Pharmacy, Vasile Goldis Western University, Arad, Romania. Email: claudiumorgovan@yahoo.com. https://orcid.org/0000-0003-2730-8729
Elisabeta ATYIM Kölcsey Ferenc National College, Satu Mare, Romania. Corresponding author: dpatyim@yahoo.co.uk.

DOI:

https://doi.org/10.24193/subbchem.2017.1.13

Keywords:

Aristolochia clematitis, hydrogel, methylcellulose, pH, swelling parameters

Abstract

The aim of this study is to embed the active ingredients of the hydroalcoholic extract from the aristolochia (Aristolochia clematitis) into a new semisolid preparation and a viscoelastic methylcellulose based hydrogel in order to broaden the topical applicability of the palette’s range. The methylcellulose based hydroalcoholic gel formulation, preparation and quality evaluation was realized by continuously measuring the product’s physico-chemical parameters. The evaluated physico-chemical parameters: the swelling degree, the equilibrium swelling degree, the swelling rate and the swelling fraction, the swelling rate parameter, the swelling kinetics order, the speed constant.

References

Lavinia Vlaia, Ioana Olariu, Georgeta Coneac, Ana Maria Muţ, V. Vlaia, Z. Szabadai, D. Lupuleasa, Practica farmaceutica, 2015, 8, 5.

N.A. Peppas, P. Bures, W. Leobandung, H. Ichikawa, European Journal of Pharmaceutics and Biopharmaceutics, 2000, 50, 27.

J. Siepmann, R. Siegel, M. Rathbone, Fundamentals and Applications of Controlled Release Drug Delivery, Eds. Spinger, New York, NY, 2012, 75.

Iuliana Popovici, D. Lupuleasa, Tehnologie farmaceutică, Eds. Polirom, 2008, Tom 2, 1500.

D. Košťálová, V. Hrochová, N. Pronayová, J. Leško, Chemical Papers, 1991, 45 (5), 713.

Heinrich, M., Chan, J., Wanke, S., Neinhuis, C., & Simmonds, M.S., Journal of Ethnopharmacology, 2009, 125 (1), 108.

Camelia Papuc, Maria Crivineanu, G. Goran, V. Nicorescu, Nicoleta Durdun, Revista de Chimie, 2010, 61, 7, 619.

Laura Vicaş, Practica farmaceutică, 2012, 5, 23.

A. Barati, H. Norouzi, S. Sharafoddinzadeh, R. Davarnejad, World Applied Sciences Journal, 2010, 11 (11): 1336.

A.S. Kipcak, O. Ismail, I. Doymaz, S. Piskin, Journal of Chemistry, 2014, Volume 2014, Article ID 281063, 8 pages.

M. Sadeghi, G. Koutchakzadeh, Journal of Sciences (Islamic Azad University), 2007, 17, 19.

J.R. Quintana, N.E. Valderruten, I. Katime, Langmuir, 1999, 15, 4728.

F. Ganji, S. Vasheghani-Farahani, E. Vasheghani-Farahani, Iranian Polymer Journal, 2010, 19 (5), 375.

G.W. Davidson, N.A. Peppas, Journal of Controlled Release, 1986, 3, 243.

Ch. Chang, B. Duan, J. Cai, L. Zhang, European Polymer Journal, 2010, 46, 92.

Elena Dinte, M. Todica, C.V. Pop, S. E. Leucuta, Studia UBB Physica, 2008, LIII, 55.

A. Kostić, B. Adnadjević, A. Popović, Jelena Jovanović, Journal of the Serbian Chemical Society, 2007, 72 (11), 1139.

*** Romanian Pharmacopoeia X (RP X), Eds. Editura Medicală, Bucuresti, 1993, 1315.

STUDIA UBB CHEMIA, Volume 62 (LXII), No. 1, March 2017

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Published

2017-03-30

How to Cite

ATYIM, P. ., OLAH, N.-K. ., OSSER, G. ., TOMA, C.-C., MORGOVAN, C. ., & ATYIM, E. . (2017). PRACTICAL INVESTIGATION OF GELS CONTAINING ARISTOLOCHIA (ARISTOLOCHIA CLEMATITIS) EXTRACT. Studia Universitatis Babeș-Bolyai Chemia, 62(1), 153–164. https://doi.org/10.24193/subbchem.2017.1.13