RESVERATROL AND LORATADINE EFFECTS ON OXIDATIVE STRESS INDUCED BY EXPERIMENTAL INFLAMMATION
DOI:
https://doi.org/10.24193/subbchem.2017.1.07Keywords:
antioxidants, inflammation, loratadine, oxidative stress, resveratrolAbstract
Resveratrol is a polyphenol with important antioxidant and anti-inflammatory roles. Loratadine, as a selective inverse-agonist of peripheral receptor H1, is described as an anti-allergic substance with potential anti-inflammatory effects. We aimed to assess the protective capacity of loratadine against oxidative stress produced by inflammation with carrageenan in comparison with a well-known antioxidant compound, resveratrol. Our results showed that resveratrol and loratadine had no protective anti-inflammatory effects in inflamed skin. As expected, resveratrol had antioxidant effects in serum and in liver. Loratadine developed oxidative stress in tegument and serum. In this experimental model, our results do not sustain the initial hypothesis that loratadine could have a protective effect in inflammation, and, on the other hand, is capable of increasing it, by producing an oxidative stress.
References
M. Matsubara, Biochem Pharmacol, 2005, 69, 433.
B. Tian, A.R. Brasier, Recent Prog Horm Res, 2003, 58, 95.
A.R. Brasier, Cardiovascular Toxicology, 2006, 6(2), 111.
S. Sas, D.K. Das, Inflamm Allergy Drug Targets, 2007, 6 (3), 168.
R.L.Wu, J.C. Anthes, W. Kreutner, A.G. Harris, R.E. Jr. West, Int Arch Allergy Immunol, 2004, 135 (4), 313.
F.R.F. Silva, C.M.P.G. Dore, C.T. Marques et al, Carbohydrate Polymers, 2010, 79, 26.
C.A. De la Lastra, I. Villegas, Biochemical Society Transactions, 2007, 35 (Pt 5), 1156.
L.A. Martins, B.P. Coelho, G. Behr, et al., Cell Biochem Biophys, 2014, 68, 247.
C. Harris, J.M. Hansen, Methods in Molecular Biology, 2012, 889, 325.
L. Yuan, N. Kaplowitz, Molecular Aspects of Medicine, 2009, 30(1-2), 29.
H.J. Forman, H. Zhang, A. Rinna, Molecular Aspects of Medicine, 2009, 30 (1-2), 1.
M. Ruweler, M. Gulden, E. Maser, M. Murias, H. Seibert, Chemico-Biological Interactions, 2009,182 (2-3), 128.
N. Hamadi, A. Mansour, M.H. Hassan, F. Khalifi-Touhami, O. Badary, J Biochem Molecular Toxicology, 2012, 26(10), 384.
G. Liu, Z. Zhang, B. Yang, W. He, Journal of Medicinal Plants Research, 2012, 6(2), 325.
M.M. Poulsen, P.F. Vestergaard, B.F. Clasen, et al., Diabetes, 2013, 62, 1186.
R.D. Semba, L. Ferrucci, B. Bartali, et al., JAMA Intern Med, 2014, 174(7), 1077.
M. Gentilli, J.X. Mazoit, H. Bouaziz, et al., Life Sci, 2001, 68(11), 1317-21.
A.R. Martin, I. Villegas, M. Sánchez-Hidalgo, C. Alarcón de la Lastra, Br J Pharmacol, 2006, 147(8), 873.
J. Tomé-Carneiro, M. Larossa M, M.J. Yáňez-Gascón, et al., Pharmacol Res, 2013, 72, 69.
R. Leurs, M.K. Church, M. Tagliatela, Clinical and Experimental Allergy, 2002, 32(4), 489.
G.W. Canonica, M. Blaiss, World Allergy Organ J, 2011, 4(2), 47-53.
K.C. Cheng, J.Y. Hsu, L.S. Fu, W.C. Chang, J.J. Chu, C.S. Chi, J Microbiol Immunol Infect, 2006, 39, 206.
C. Amsellen, W. Czarlewki, M. Lagarde, Y. Pachéco, Pulmonary Pharmacology & Therapeutics, 1998, 11(4), 245.
O. Letari, A. Miozzo, G. Folco, P.A. Belloni, A. Sala, G.E. Rovati, S. Nicosia, Eur J Pharmacol, 1994, 15, 266(3), 219.
R.M. Naclerio, Ann Allergy, 1993, 71(3), 292.
J.T. Schroeder JT, R.P. Schleimer, L.M. Lichtenstein, W. Keutner, Clin Exp Allergy, 2001, 31(9), 1369.
I. Sadowska-Woda, B. Sychta, M. Rachel, E. Bieszczad-Bedrjczuk, Environmental Toxicology and Pharmacology, 2010, 30(2), 141.
N. Yumibe, K. Huie, K.J. Chen, M. Snow, R.P. Clement, M.N. Cayen, Biochem Pharmacol, 1996, 51, 165.
B. Katchen, J. Crame, M. Chung, Ann Allergy, 1985, 55, 393.
M. Conti, P.C. Morand, P. Levillain, A. Lemonnier, Clinical Chemistry, 1991, 37, 1273.
M.L. Hu, Methods in Enzymology, 1994, 233, 380.
P. Vats, V.K. Singh, S.S. Sing, Aviation, Space and Environmental Medicine, 2008, 79 (12), 1106.
A. Janaszewska, G Bartosz, Scandinavian Journal of Clinical and Laboratory Investigation, 2002, 62 (3), 231.
C.E. Pippenger, R. W. Browne, D. Armstrong, Methods in Molecular Biology, 1998, 108, 299.
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