7-AMINOCEPHALOSPORANIC ACID – PRODUCTION AND SEPARATION
DOI:
https://doi.org/10.24193/subbchem.2019.2.08Keywords:
7-aminocephalosporanic acid, cephalosporin C, enzymatic reaction, pertraction, reactive extractionAbstract
Cephalosporins, a large group of β-lactam antibiotics, contain a 7-aminocephalosporanic acid (7-ACA) nucleus which is derived from cephalosporin C, and substitutions of chemical groups or modifications of 7-ACA side-chains resulting in varying pharmacologic properties and antimicrobial activities, development of useful antibiotic agents, also. Cephalosporin C obtained by fungus fermentation can be transformed to 7-ACA by two-step or one step enzymatically conversion process. The most important step in 7-ACA downstream process is represented by its separation from enzymatically produced reaction mixture. Among the used methods new separation techniques have been developed and applied to bioseparations, like reactive extraction and pertraction which have considerable potential.
References
R.P. Elander, Applied Microbiology and Biotechnology, 2003, 61, 385.
A. Magdaleno, M.E. Saenz, A.B. Juarez, J. Moretton, Ecotoxicology and Environmental Safety, 2015, 113, 72.
J.C. Kim, Y.S. Song, D.H. Lee, S.W. Kang, S.W. Kim, Biotechnology Letters, 2007, 29(1), 51.
M.S. Barber, U. Giesecke, A. Reichert, W. Minas, Advances in Biochemical Engineering / Biotechnology, 2004, 88, 179.
L.L. Brunton, B.A. Chabner, B.C. Knollman, "The pharmacological basis of therapeutics", McGraw-Hill Medical, New York, 2011.
H. Gröger, M. Pieper, B. König, T. Bayer, H. Schleich, Sustainable Chemistry and Pharmacy, 2017, 5, 72.
L. Pollegioni, E. Rosini, G. Molla, Applied Microbiology and Biotechnology, 2013, 97(6), 2341.
H. Luo, H.M. Yu, Q. Li, Z.Y. Shen, Enzyme and Microbial Technology, 2004, 25, 514.
F. Lopez-Gallego, L. Batencor, A. Hidalgo, C. Mateo, R. Fernandez-Lafuente, J.M. Guisan, Advanced Synthesis & Catalysis, 2005, 347, 1804.
Q. Tan, Q. Song, D. Wei, Enzyme and Microbial Technology, 2006, 39, 1166.
G. Conti, L. Pollegioni, E. Rosini, Catalysis Science & Technology, 2015, 5, 1854.
V.K. Nigam, S. Kundu, P. Ghosh, Applied Biochemistry and Biotechnology, 2005, 126, 13.
V.C. Sonawane, Critical Reviews in Biotechnology, 2006, 26, 95.
L. Pollegioni, S. Lorenzi, E. Rosini, G.L. Marcone, G. Molla, R. Verga, W. Cabri, M.S. Pilone, Protein Science, 2005, 14, 3064.
D. W.Hardianto, B. Isdiyono, F.X. Ivan, Indonesia Journal of Biotechnology and Biosciences, 2016, 3, 89.
F.M. Huber, P.R. Chauvette, B.G. Jackson, "Cephalosporins and penicillins: Chemistry and Biology", Academic Press, New York, 1972.
A.C. Ghosh, R.K. Mathur, N.N. Dutta, Advances in Biochemical Engineering / Biotechnology, 1997, 56, 111.
M.M. Bora, N.N. Dutta, K.G. Bhattacharya, Journal of Chemical & Engineering Data, 1998, 43, 318.
W.Q. Guo, H.S. Zheng, S. Li, J.S. Du, X.C. Feng, R.L. Yin, Q.L. Wu, N.Q. Ren, J.S. Chang, Bioresource Technology, 2016, 221, 284.
G.C. Sahoo, A.C. Ghosh, N.N. Dutta, R.K. Mathur, Journal of Membrane Science, 1996, 112, 147.
D. Cascaval, L. Kloetzer, A.I. Galaction, Journal of Chemical & Engineering Data, 2011, 56(6), 2521.
M.M. Bora, N.N. Dutta, K.G. Bhattacharya, Chemical Engineering Communications, 2000, 179, 15.
M.M. Bora, S. Borthakur, P.G. Rao, N.N. Dutta, Chemical Engineering and Processing, 2008, 47, 1.
D. Cascaval, M. Postaru, A.I. Galaction, L. Kloetzer, A.C. Blaga, Industrial & Engineering Chemistry Research, 2013, 52, 2685.
A.C. Ghosh, S. Borthakur, M.K. Roy, N.N. Dutta, Separations Technology, 1995, 5, 121.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2019 Studia Universitatis Babeș-Bolyai Chemia
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
