Correlations Between Oxidative Stress Markers and Coronary Anatomy in Percutaneously Treated Patients With Acute ST-elevation Myocardial Infarction

Abstract

Understanding biochemical mechanisms involved in acute myocardial infarction is crucial for future treatments. The current study analyzed the oxidative stress markers in patients with percutaneously treated acute ST-elevation myocardial infarction and correlated the findings to coronary anatomy and Syntax II score (SS-II). Blood samples were obtained before coronary re-perfusion, after one and 24 hours. The following markers of oxidative stress were determined: malondialdehyde (MDA), reduced glutathione to oxidized glutathione ratio (GSH/GSSG) and total antioxidant capacity (TAC). Thirty-seven consecutive patients were included. The patients were divided into groups according to the infarct-related artery: left anterior descending artery (LAD- group) vs non-LAD group, and according to the calculated SS-II, SS-II≤ 34 vs. SS-II>34. MDA concentration and GSH/GSSG ratio showed non-significant differences between LAD vs non-LAD groups at all time frames. Patients with LAD as the infarct-related artery had a significantly lower TAC 24 hours after re-perfusion: 30.22 ± 9.78 % inhibition in the LAD group vs. 35.7 ± 5.78 % inhibition in the non-LAD group, p=0.013. The oxidative stress markers were similar between patients regardless of the SS-II value, and neither the culprit vessel nor the SS-II significantly influenced the dynamics of oxidative stress markers.